An Investigation into the Solubility and Solution Thermodynamics of Cefpodoxime Proxetil in Different Solvents that Vary with Temperature

Bhola, Ravibhai; Vaghani, H. V.; Bhatt, Keyur D.; Parikh, Jaymin; Ghumara, Rizwan

doi:10.1007/s42250-022-00364-x

Cited by 5 publications

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References 30 publications

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“…The average relative deviation (ARD) and the root mean square deviation (RMSD) were utilized to determine the fitting effect of the different solubility models. − For the calculation, the following equations are used: ARD = 1 n ∑ i n ( x exp − x cal x exp ) RMSD = true[ ∑ i = 1 n ( x cal − x exp n ) true] 1 / 2 where x exp , x cal , and n signify the experimental mole-fraction solubility of BTC and the calculated mole-fraction solubility of BTC by various models and the number of observation data points, respectively.…”

Section: Methodsmentioning

confidence: 99%

Solubility and Thermodynamics Profile of Benzethonium Chloride in Pure and Binary Solvents at Different Temperatures

et al. 2023

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Benzethonium chloride (BTC) has various applications in several industries. The solubility and solution thermodynamic properties of BTC were measured. The solubility of BTC in methanol, ethanol, 1-propanol, 2-propanol, 1butanol, water, dimethyl sulfoxide, acetic acid, and dimethyl formamide neat solvents and methanol + water and ethanol + water binary solvents at 298.15−318.15 K over an atmospheric pressure was measured. The solubility data of BTC is positively related to the temperature in all selected solvents. The solubility data was fitted by the Apelblat model, λh model, Yaws model, Van't Hoff equation, CNIBS/R-K model, and modified Jouyban−Acree equation. The RMSD and ARD were chosen to evaluate the fitting of each model. The dissolution thermodynamic parameters, enthalpy of the solution, entropy of the solution, and Gibbs energy of the solution were calculated. The solubility data and dissolution thermodynamic parameters of BTC will provide significant guidance for purification, crystallization, and separation in various areas.

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