An Investigation of Anti-inflammatory Effects of Famotidine in Rats by Evaluating Inflammatory Cells and Lung Histopathology: An Airway Model

Abstract

P ersistent respiratory conditions like asthma and chronic obstructive pulmonary disease (COPD) remain significant global challenges for individuals and healthcare systems due to respiratory complications, prolonged hospitalization, and heightened mortality risks (Liccardi et al., 2012). Typically, asthma involves immune system activation, leukocytes infiltration, excessive mucus production, and remodeling of the airways (Boonpiyathad et al., 2019, Athari, 2019. Moreover, COPD has emerged as a significant contributor to mortality and has been classified as the third leading cause of death worldwide (Sritharan et al., 2021, Lee andSin, 2022). Individuals with COPD face a heightened risk of infection, lung cancer, and sudden occurrences of acute pulmonary embolism (Lopez-Campos et al., 2014, Patel andPriefer, 2022).