An investigation of brain tumours and other malignancies in an agricultural research institute.

Daly, L.; Herity, B A; Bourke, G J

doi:10.1136/oem.51.5.295

Cited by 22 publications

(39 citation statements)

References 6 publications

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“…The choice of the total French population as a reference was justified, since rare forms of cancer were involved. Nevertheless, our results are consistent with those of previous studies as regards the mortality from cancer among scientists potentially exposed to mixtures of chemicals, such as chemists or biologists (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). The statistical power of the study only allowed the detection of high risks.…”

Section: Discussionsupporting

confidence: 82%

“…The cases were all subjects identified as having had one of the following diagnoses: non- These types of cancer were chosen a priori as having been linked in some instances with the work environment of chemists and laboratory workers (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). Cases of decedents (N = 17) were identified from death certificates, and incident cases (N = 6) were gathered from the answers the questionnaire, or from occupational medical records for those who had a file in 1987 but had not answered the questionnaire.…”

Section: Nested Case-referent Studymentioning

confidence: 99%

“…Cohorts of such workers have been studied in the United States (2)(3)(4)(5)(6)(7)(8), in the United Kingdom (9)(10)(11)(12), Sweden (l3), Italy (14), and Ireland (15). The most recent studies show that the overall mortality caused by cancer among these workers is lower than among the general population.…”

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confidence: 99%

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Cancer risk among workers in biomedical research

Cordier¹,

Mousel²,

Goaster³

et al. 1995

Scand J Work Environ Health

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Objective This epidemiologic study was undertaken after a cluster of five cases of rare forms of cancer (bone sarcoma, non-Hodgkin's lymphoma) had been observed among biomedical research workers at the Pasteur Institute in Paris to ascertain whether their disease was connected with exposure during this research. Methods A mortality study included 3765 people who worked at the Pasteur Institute between 1971 and 1986 and were followed until the end of 1987. Within this cohort a nested case-referent study included 23 cases of cancer [non-Hodgkin's lymphoma (6), multiple myeloma (I), leukemia (3), pancreatic cancer (7), bone cancer (3), brain tumor (3)], and four referents per case, matched for gender and year of birth. Results Total mortality from cancer was less than expected, the standardized mortality ratio (SMR) being 72 for the men and 82 for the women. Among the women the proportion of pancreatic cancer cases was larger than expected [SMR 490, 95% confidence interval (95%CI) 158-1144], as was the number of brain cancer cases (SMR 239, 95% CI 48-696). Among the men, mortality from bone cancer was greater than expected (SMR 553,95% CI 62-2006). In the nested case-referent study, more cases than referents had worked in the areas of molecular biology [odds ratio (OR) 7.1, 95% CI 1.5-331 and microbial genetics (OR 6.7, 95% CI 1.3-35). These cases especially included non-Hodgkin's lymphoma and bone cancer. Associated with this finding was the fact that more cases had used certain chemicals, including ethidium bromide, acrylamide, methylnitronitrosoguanidine and ethylmethanesulfonate, and radioactive compounds (essentially 32phosphorus). C O~~C~U S~O~~S As the products used are potent genotoxicants, the present findings suggest that work in biomedical research might well involve an increased risk of certain types of cancer; this conclusion should be balanced by the fact that two of the five index cases were included in the mortality study and four in the nested casereferent study.

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Section: Discussionsupporting

confidence: 82%

Section: Nested Case-referent Studymentioning

confidence: 99%

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Cancer risk among workers in biomedical research

Cordier¹,

Mousel²,

Goaster³

et al. 1995

Scand J Work Environ Health

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“…In the UK, analysis of cancer registrations among chemists, physical or biological scientists and laboratory assistants showed a small excess of brain and nervous system cancers, but was otherwise unremarkable (Carpenter et al, 1991). Two studies of people working in agricultural research have indicated increased risks of lymphoma and cancer of the colon, and of brain, bladder and heamatopoietic cancer (Dosemeci et al, 1992;Daly et al, 1994). In our study elevated mortality was observed from malignant melanoma, other skin cancer, cancers of the uterine body and thyroid, multiple myeloma and leukaemia, but none of these was statistically significant.…”

Section: Methodsmentioning

confidence: 99%

Mortality pattern among biological research laboratory workers

Brown

Paulson²,

Pannett³

et al. 1996

Br J Cancer

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Summary A cohort study was conducted to investigate the mortality of individuals employed by biological research institutes in the UK. The inclusion criteria were met by 12703 individuals, of whom 95% were traced (11 502 alive, 395 deaths, 246 embarkations). All-cause mortality was significantly reduced in men (standardised) mortality ratio (SMR) 55 and women (SMR 52). Mortality was also significantly reduced for circulatory and respiratory diseases, and overall there was low mortality from malignant neoplasms. SMRs exceeded 100, but were not statistically significant, for infective and parasitic diseases. There were no statistically significant raised SMRs for any cancer site. Workers were categorised as ever worked in a laboratory (laboratory workers) and never worked in a laboratory (non-laboratory workers). The all-cause SMR was significantly reduced in both groups, as was mortality from circulatory and respiratory diseases. The SMR for malignant neoplams was also significantly reduced in laboratory workers. On the basis of follow-up to 31 December 1994, there is no evidence of any overall increased risk of mortality in biological research laboratory workers. However, the power of the analysis is limited by the young age of many cohort members and short duration of follow-up. Follow-up is continuing and the data will be reanalysed once more deaths have accumulated.

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“…Following the discovery of a cluster of uncommon cancer types in the Pasteur Institute in Paris, an independent investigation was conducted and in parallel it was decided to perform a multicenter study in eight European countries (Finland, France, Ireland, Italy, Netherlands, Norway, Sweden, and the United Kingdom) as part of an IARC (International Agency for Research on Cancer) initiative [Sasco, 1992]. Some of these studies showed a slightly increased mortality for brain tumors [Belli et al, 1992;Cordier et al, 1995], for hematopoietic system malignancies [Belli et al, 1992], pancreatic cancer [Belli et al, 1992;Cordier et al, 1995], bone cancer , bladder cancer [Daly et al, 1994], as well as breast cancer in women [Belli et al, 1992]. However, in a British study [Brown et al, 1996], no excess for brain or pancreatic tumors was found.…”

Section: Introductionmentioning

confidence: 98%

Mortality and cancer incidence in biomedical laboratory personnel in Sweden

et al. 1999

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Background: The work in biomedical laboratories is associated with exposure to a mixture of known and potential chemical carcinogens, mutagens, and teratogens. Previous studies have suggested an excess of brain tumors and hematopoietic system malignancies as well as breast cancers in women. Methods: This retrospective cohort study investigated the standardized mortality ratio (SMR) and the standardized incidence ratio (SIR) for cancer in biomedical research laboratory personnel in Swedish universities 1970–1992. The cohort comprised 5,035 laboratory and, as an internal reference group, 2,923 nonlaboratory employees. Results: The overall death rate was lower in both groups than in the general population. The SIR for brain tumors among male laboratory workers was 1.69 (0.62–3.68) and among male laboratory scientists, after more than 10 years of work (4 cases), it was 3.11 (0.85–7.56). There was an elevated SIR for malignant melanoma among female scientists in laboratories (3.51, 0.96–8.98) and for male scientists in nonlaboratory departments (2.86, 1.05–6.22). The SIR for breast cancer among female laboratory scientists was 1.62 (0.78–2.98). Conclusions: The present findings lend some support to an excess of brain tumors among male scientists and of breast cancer in female scientists in biomedical research laboratories. Am. J. Ind. Med. 35:382–389, 1999. © 1999 Wiley‐Liss, Inc.

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An investigation of brain tumours and other malignancies in an agricultural research institute.

Cited by 22 publications

References 6 publications

Cancer risk among workers in biomedical research

Cancer risk among workers in biomedical research

Mortality pattern among biological research laboratory workers

Mortality and cancer incidence in biomedical laboratory personnel in Sweden

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