An Investigation of Factors Increasing the Risk of Aggressive Behavior among Schizophrenic Inpatients

Lejoyeux, Michel; Nivoli, Fabrizia; Basquin, Anne; Petit, Aymeric; Chalvin, Florence; Embouazza, Houcine

doi:10.3389/fpsyt.2013.00097

Cited by 26 publications

(22 citation statements)

References 24 publications

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“…Both found that higher SNS levels were correlated with higher scores on the Overt Aggression Scale (OAS), but in the study of Lejoyeux et al [49] SS did not appear in the logistic regression to be a risk factor for aggressive behavior (Table 6). Herrán et al [46] 62 schizophrenia outpatients, 43 healthy subjects NS, TPQ Disability Several personality traits, but not NS were associated with disability.…”

Section: Ns Tci No Association Of Ns With Suicide Attemptsmentioning

confidence: 76%

Sensation/novelty seeking in psychotic disorders: A review of the literature

Peritogiannis¹

2015

WJP

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The evaluation of personality traits is important for the better understanding of the person suffering from psychosis and for treatment individualization. However literature on patients' personality and character in such disorders is limited. The aim of this review was to summarize the literature on sensation/novelty seeking (SNS), a trait which is biologically based and highly heritable and is associated with dopamine activity, and refers to a person's tendency to seek varied, novel, complex, and intense sensations and experiences. A total of 38 studies were included in this review, involving 2808 patients and 2039 healthy controls. There is consistent evidence that this trait is independently associated with alcohol and substance abuse in patients with schizophrenia and related disorders. The estimation of SNS would help clinicians to identify patients at risk for abuse. There is also some evidence that higher SNS levels may relate to medication non-adherence and seem to increase the risk of patients' aggressive and violent behavior, but studies are scarce. SNS was found not to be related to suicidality, whereas in the fields of patients' quality of life and psychopathology results are contradictory, but most studies show no possible association. Several studies suggest that SNS is lower in psychotic patients compared to controls, whereas most yield no differences. The evidence for this trait as a potential endophenotype of schizophrenia is weak. SNS may be implicated in psychotic disorders' course and prognosis in several ways and should be always inquired for. This trait can be reliably measured with the use of easily applicable self-rated instruments, and patients' accounts could inform clinicians when planning management and delivering individualized treatment. Core tip: This review summarizes current research on the personality trait sensation/novelty seeking (SNS) in psychotic disorders. There is an emerging literature on SNS in psychotic patients, suggesting that this trait is associated with patients' alcohol and substance misuse. Some evidence suggests that SNS may be related to medication non-adherence and aggressive behavior, whereas data on other illness dimensions, such as quality of life and psychopathology are scarce and controversial. In general, patients with psychotic disorders appear to have lower SNS levels than healthy controls, but abusing patients, who probably have high SNS levels are often excluded from research. REVIEWSubmit a

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Section: Ns Tci No Association Of Ns With Suicide Attemptsmentioning

confidence: 76%

Sensation/novelty seeking in psychotic disorders: A review of the literature

Peritogiannis¹

2015

WJP

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“…A UK study using the Overt Aggression Scale (OAS) reported a very high level of aggression – both verbal aggression (M:F= 52%:46%) and aggression against objects (M:F=39%:34% ) in a sample of 136 males and 44 females suffering from Schizophrenia (Reague et al., 2013). A similar study using OAS in 100 inpatients reported that violence was more common among males (odd ratio = 12.8) (Lejoyneux et al., 2013). …”

Section: Discussionmentioning

confidence: 95%

A cross sectional study of prevalence and correlates of current and past risks in schizophrenia

Jakhar

Bhatia

Saha

et al. 2015

Asian Journal of Psychiatry

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Background The growing burden of chronic often untreated mental illness has increased the importance of risk assessment in people suffering from major mental disorders. Aims The present study was undertaken to obtain prevalence of various risks and predictive factors for self-harm, violence and various other risks among randomly recruited Schizophrenia subjects (n=270) on the basis of past history of their disorder. Method Using a rigorous translation, back translation and acceptability process, a specially constructed semi-structured assessment interview, based on a prior NHS Trust risk assessment interview along with the Diagnostic Interview for Genetic Studies, detailed information was obtained for various risks. Results Risk of violence (historical) was reported among 65.55%, and risk of self-neglect among 53.33%, risk to others (47.41%), risk of coming to harm (24.07%), self-harm (22.59%), risk from others (11.85%), fire risk (2.96%) Risk of violence (historical) and risk to others was related to ‘ever’ having emotions related to harm and self-harm, ‘current’ emotions related to violence and poor compliance to treatment. Conclusion Regular risk assessment is essential to assess emotions related to violence and non-adherence to treatment. Assessment of risk helps clinicians predict the risks involved in management and in timely intervention.

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“…Rehospitalization [3], severe psychotic symptoms [4], partial adherence or nonadherence to antipsychotic medication [5], poor quality of life, and aggressive behavior [6] are common among patients with schizophrenia. Although typical and atypical antipsychotics remain as the core intervention strategy, partial or nonadherence levels to medication for schizophrenia patients reaches 60% due to the lack of insight of their illness [3] and the severe side effects of medications [7,8,9].…”

Section: Introductionmentioning

confidence: 99%

Effect of Community-Based Social Skills Training and Tai-Chi Exercise on Outcomes in Patients with Chronic Schizophrenia: A Randomized, One-Year Study

Kang

Wu²,

Li³

et al. 2016

Psychopathology

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Background: Antipsychotic drugs are limited in their ability to improve negative symptoms, quality of life, and medication adherence in patients with schizophrenia. The addition of nonpharmacological interventions like social skills training has a positive effect on medication adherence and decreases rehospitalization rates but is limited in improving patients' symptoms, aggressive behaviors, and quality of life. Aerobic exercise, especially Tai-chi, can potentially reduce psychopathological and negative symptoms, decrease aggressive behaviors, and improve quality of life. It is an ideal rehabilitation intervention for patients with schizophrenia. However, no study has investigated the effects of social skills training plus Tai-chi on outcomes among outpatients with schizophrenia. This study analyzes the effect of antipsychotics combined with community-based integrated interventions on outcomes of schizophrenia. Methods: In this study, a 24-session social skills training plus Tai-chi was used in community settings among patients with schizophrenia. A total of 244 patients were randomly assigned to medication treatment alone (MTA group) or community-based integrated intervention (CBII group), which accepted social skills training plus Tai-chi in addition to medication treatment. Generalized linear mixed models were used to evaluate the intervention effect (group effect), intervention effect over time (time effect), and interaction effect (group × time effect). t tests were used to evaluate between-group differences on clinical variables. Multiple linear regression analysis was used to analyze the differences between the intervention at 12 months and baseline for the Positive and Negative Syndrome Scale (PANSS) negative symptoms and quality of life-social domain. Results: Compared with the MTA group, the CBII group had lower scores on PANSS (F = 17.312, p < 0.001) and negative symptoms (F = 44.909, p < 0.001), a lower risk for aggressive behavior (F = 12.382, p < 0.001), and a greater improvement in adherence to medication (F = 12.391, p < 0.001) after 1 year of intervention. The changes in PANSS total scores, negative scores, and social domain of the World Health Organization Quality of Life Scale-Brief version (WHOQOL-BREF) from baseline to 12 months were significant between the two groups (PANSS total score: t = 4.839, p < 0.001; negative symptoms: t = 8.250, p < 0.001, and quality of life-social domain: t = -2.171, p = 0.031). Multiple linear regression analysis also showed that the intervention was significantly effective for changes from baseline to 12 months on PANSS total score (B = 0.804, p < 0.001), negative score (B = 0.709, p < 0.001), and social domain of quality of life (B = -0.673, p = 0.044). Conclusions: This study suggested that the community-based integrated intervention such as social skills training plus Tai-chi should be part of a rehabilitation effort for patients with schizophrenia in order to improve clinical symptoms, quality of life, and medication adherence.

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An Investigation of Factors Increasing the Risk of Aggressive Behavior among Schizophrenic Inpatients

Cited by 26 publications

References 24 publications

Sensation/novelty seeking in psychotic disorders: A review of the literature

Sensation/novelty seeking in psychotic disorders: A review of the literature

A cross sectional study of prevalence and correlates of current and past risks in schizophrenia

Effect of Community-Based Social Skills Training and Tai-Chi Exercise on Outcomes in Patients with Chronic Schizophrenia: A Randomized, One-Year Study

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