An Investigation of Kutapressin as a Hemostatic Agent in Transurethral Surgery of the Prostate

Weisenthal, Charles L.; Meade, Robert C.; Owenby, Jacqueline; Irwin, R. John

doi:10.1016/s0022-5347(17)65175-9

Cited by 5 publications

(1 citation statement)

References 14 publications

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“…Many drugs have been tried to reduce postprostatectomy haemorrhage but none has been of any use : e.g., carbazochrome salicylate (Frank and Lloyd, 1959), Kutapressin (Weisenthal et al, 1961), Premarin (Madsen et al, 1964), polyoestradiol phosphate (Madsen el al., 1968) and aprotinin (Pearson, 1969). Only epsilon aminocaproic acid (Lawrence, Ward, McQuaid and Holdom, 1966;Madsen and Strauch, 1966;Vinnicombe and Shuttleworth, 1966) has been found to reduce postoperative blood loss by 30 % to 60 % but it has no effect on bleeding during operation.…”

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The Effect of Dicynene on Blood Loss during and after Transurethral Resection of the Prostate

Symes

Offen

Lyttle

et al. 1975

British Journal of Urology

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The effect of Dicynene on blood loss during and after transurethral resection for benign enlargement of the prostate was studied in 76 patients. Median loss of blood at operation was 17 ml in those given Dicynene compared with 72 ml in the placebo group (p equals less than 0.001). Median postoperative blood loss was 38 ml in the Dicynene group, and 103 ml in the placebo group (p equals 0.05). Clinical evidence of deep vein thrombosis was found in neither group. Dicynene helps to reduce blood loss in transurethral resection.

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mentioning

confidence: 99%

The Effect of Dicynene on Blood Loss during and after Transurethral Resection of the Prostate

Symes

Offen

Lyttle

et al. 1975

British Journal of Urology

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Differential Staining Cytotoxicity Assay: A Review

Weisenthal

2011

Methods in Molecular Biology

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Differential Staining Cytotoxicity (DiSC) assay is the prototype for a closely related family of assays based on the concept of total cell kill, or, in other words, cell death occurring in the entire population of tumor cells. It is probably the most versatile of the cell-death end points, in that it (1) can be applied to both solid and hematologic neoplasms, (2) can be applied to specimens in which it is not possible to obtain a pure population of highly enriched tumor cells, and (3) can be applied to a wide variety of drugs, ranging from traditional cytotoxic agents to biological response modifiers with activity mediated through tumor-infiltrating effector cells, to "targeted" kinase inhibitors, and to antivascular agents, such as bevacizumab and pazopanib. The basic principles of the assay are to culture three-dimensional fresh tumor cell clusters in anchorage-independent conditions. At the conclusion of the culture period, Fast Green dye is added to the microwells, the contents of which are then sedimented onto permanent Cytospin centrifuge slides and then counterstained with hematoxylin-eosin or Wright-Giemsa. "Living" cells stain with the cytologic stain in question and can be identified as either normal or neoplastic, based on standard morphologic criteria. "Dead" cells stain blue-green. Nonviable endothelial cells appear as strikingly hyperchromatic, blue-black, and often refractile objects, which may be readily distinguished from other types of dead cells. This assay has been biologically and clinically validated in a number of ways, as described in this chapter.

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The Effect of Aminocaproic Acid on Bleeding Following Transurethral Prostatectomy

Madsen

Strauch

1966

Journal of Urology

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An Investigation of Kutapressin as a Hemostatic Agent in Transurethral Surgery of the Prostate

Cited by 5 publications

References 14 publications

The Effect of Dicynene on Blood Loss during and after Transurethral Resection of the Prostate

The Effect of Dicynene on Blood Loss during and after Transurethral Resection of the Prostate

Differential Staining Cytotoxicity Assay: A Review

The Effect of Aminocaproic Acid on Bleeding Following Transurethral Prostatectomy

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