Musculoskeletal disorders (MSDs) are the leading global cause of disability and pose a significant public health issue, particularly among professional drivers who are prone to such conditions due to prolonged sitting, poor posture, and exposure to whole-body vibrations. The objectives of this study are to assess the demographic, general, lifestyle, and wellness profiles of professional drivers, gauge their work environment characteristics, and measure the proportion of musculoskeletal symptoms using the modified Nordic questionnaire. This descriptive study collected data from 67 professional drivers at major bus stands in Lahore using a structured questionnaire. The data were analyzed using frequencies, percentages, means, and standard deviations. The results revealed that the drivers, predominantly middle-aged (average age 39.72 ± 9.53 years) and married (95.52%), reported limited formal education (average 7.56 ± 3.91 years). Lifestyle assessments indicated high rates of smoking (61.19%) and frequent consumption of soft drinks (88.06%). In their work environment, most drivers (68.66%) worked daytime shifts, and a significant proportion (56.72%) experienced vibration exposure. The most frequently reported musculoskeletal symptoms were in the lower back (58.21% in the past 12 months, 43.28% in the past 7 days) and hips/thighs (61.19% in the past 12 months), impacting their ability to work. These findings highlight the critical need for targeted ergonomic and lifestyle interventions to improve the occupational health and safety of drivers, potentially reducing musculoskeletal discomfort and enhancing overall well-being and productivity.