Aims and objectives. To describe how nurses experience caring for people with intellectual disability in an acute care setting. Background. Recent advances in the care of people with intellectual disability in hospital are primarily based upon the experiences of people with intellectual disability and their caregivers. Little is known about the experiences of registered nurses caring for people with intellectual disability, yet the experiences of nurses in delivering care largely determine the quality of care experienced by people with intellectual disability and their caregivers. Methods. A narrative literature review using electronic database searches was conducted using variants of the terms disability, nursing and acute care. Results. Through our reading of the recent literature describing the experiences of nurses caring for people with intellectual disability in an acute care setting, we have identified three themes: (1) nurses feel underprepared when caring for patients with intellectual disability, (2) nurses experience challenges when communicating with people with intellectual disability and (3) nurses have ambiguous expectations of paid and unpaid caregivers. Conclusion. The enablers of and barriers to the delivery of nursing care in acute care settings need to be made explicit and researchers and nurses need to collaborate in the development, implementation and evaluation of care delivery strategies. Relevance to clinical practice. Nurses need to be adequately prepared to care for people with intellectual disability. Preparation should include dealing with the complexities of communicating with people with intellectual disability and practical experience of doing so in clinical and educational environments that ensure the safety and dignity of nurses and people with intellectual disability. Nurses need supportive strategies for developing therapeutic relationships with a range of informal and formal caregivers.Key words: acute care, experiences of care, intellectual disability, professional communication, registered nurse, therapeutic relationships What does this paper contribute to the wider global clinical community?• This paper highlights the dearth of research into the experiences of registered nurses caring for people with ID in acute care settings.• Registered nurses might feel underprepared to care for people with ID, challenged by difficult communicative interactions, and ambivalent about caregivers' roles in providing care.• More needs to be known about the experiences of registered nurses caring for people with ID in acute care settings to develop strategies for delivering highquality, sustainable care to this patient population. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.