An investigation of relations between crystal methamphetamine use and posttraumatic stress disorder

Smith, Rose C.; Blumenthal, Heidemarie; Badour, Christal L.; Feldner, Matthew T.

doi:10.1016/j.addbeh.2010.01.010

Cited by 22 publications

(24 citation statements)

References 24 publications

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“…Individuals with PTSD report a rate of substance dependence that is 2-3 times higher than that of those without PTSD (Cottler et al 1992; Jacobsen et al 2001; Kessler et al 1995). Moreover, clinical studies have demonstrated that methamphetamine (METH) is twice as likely to be used in individuals with concurrent PTSD than in trauma-exposed individuals without PTSD (Smith et al 2010). These studies are consistent with a wider body of literature reporting a strong relationship between PTSD and substance abuse (Back et al 2000; Brady 2001; Cottler et al 1992; Khoury et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Effects of oxytocin on methamphetamine-seeking exacerbated by predator odor pre-exposure in rats

2015

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Rationale The endogenous oxytocin system has emerged as an inhibitor of drug-seeking and stress in preclinical models. Objectives The goal of this study was to examine whether systemic oxytocin administration attenuated methamphetamine (METH)–seeking in rats pre-exposed to a predator odor threat. Methods In Experiment 1, rats were exposed for five days to the predator odor, 2,5-dihydro-2,4,5-trimethylthiazoline (TMT), or saline before METH self-administration began. After extinction training, rats were injected with 1 mg/kg, ip oxytocin (OXT) or saline 30 min before a cue-induced reinstatement test followed by re-extinction and a TMT–induced reinstatement test. In Experiment 2, TMT pre-exposure was followed by 10 days of 1 mg/kg OXT or saline injections before METH self-administration, extinction, and a TMT-induced reinstatement test. Results In Experiment 1, TMT pre-exposed rats that were injected with saline 30 min before reinstatement exhibited greater drug-seeking induced by conditioned cues or TMT than that exhibited by saline pre-exposed rats. A single injection of OXT 30 min before reinstatement suppressed METH-seeking in both saline- and TMT pre-exposed rats. In Experiment 2, TMT pre-exposed rats that received saline injections for 10d prior to METH self-administration exhibited enhanced drug-seeking induced by TMT during stress-induced reinstatement. OXT injections for 10d prior to METH self-administration blocked only the stress-induced exacerbation of drug-seeking in TMT pre-exposed rats. Conclusions These results support further research on the development of oxytocin as a novel therapeutic that has enduring effects on drug-seeking exacerbated by stress.

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Section: Introductionmentioning

confidence: 99%

Effects of oxytocin on methamphetamine-seeking exacerbated by predator odor pre-exposure in rats

2015

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“…The relative absence of efforts to evaluate the unique variance in offspring problems associated with parental PTSD relative to other conditions is unfortunate as it precludes confident conclusions about the specific relation between offspring problems and parental PTSD per se. Indeed, nationally-representative estimates suggest persons with PTSD frequently suffer from major depression (Kessler, Sonnega, Bromet, Hughes, & Nelson, 1995), panic disorder (PD; Feldner et al, 2009;Kessler et al, 1995), and use substances including alcohol, cocaine, nicotine, and methamphetamines at elevated rates (Brady, Dansky, Sonne, & Saladin, 1998;Dansky, Byrne, & Brady, 1999;Feldner, Babson, & Zvolensky, 2007;Kessler et al, 1995;Mills, Teesson, Ross, & Peters, 2006;Smith, Blumenthal, Badour, & Feldner, 2010;Stewart, 1996). Importantly, these comorbid conditions are each linked with offspring problems (e.g., Biederman et al, 2001;Hammen, 2009;Marmorstein, Iacono, & McGue, 2009;Unnewehr, Schneider, Florin, & Margraf, 1998).…”

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confidence: 99%

Associations between parental posttraumatic stress disorder and both offspring internalizing problems and parental aggression within the National Comorbidity Survey-Replication

Leen‐Feldner

Feldner

Bunaciu

et al. 2011

Journal of Anxiety Disorders

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“…Given that heroin is known to be self-medicating for those suffering from PTSD (Tull et al, 2010), sex workers who have experienced violence and other traumatic life events may be self-medicating with injection CM. Higher rates of CM use have been observed among individuals with PTSD than without (Smith et al, 2010), and PTSD has been associated with poorer CM treatment outcomes (Glasner-Edwards et al, 2013). …”

Section: Discussionmentioning

confidence: 99%

Violence, trauma and living with HIV: Longitudinal predictors of initiating crystal methamphetamine injection among sex workers

Argento

Strathdee

Goldenberg

et al. 2017

Drug and Alcohol Dependence

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Background Despite rapid increases in crystal methamphetamine (CM) use worldwide and established gendered patterns of use, empirical research on CM injection initiation among sex workers is limited. Given the wide range of harms associated with CM, alongside stimulant effects including sexual dis-inhibition and prolonged awake-ness, this study aimed to longitudinally investigate socio-structural predictors of initiating CM injection among sex workers in Vancouver, Canada. Methods Data (2010–2014) were drawn from a community-based cohort of women sex workers: AESHA (An Evaluation of Sex Workers Health Access). Participants completed biannual interviewer-administered questionnaires and HIV/STI testing. Kaplan Meier methods and Cox proportional hazards regression were used to model predictors of CM injection initiation among CM injection-naïve participants. Results Of 455 participants eligible at baseline, 14.3% (n=65) injected CM for the first time over follow-up, with an incidence density of 6.79 per 100 person-years (95% Confidence Interval [CI] 5.30–8.69). In multivariable analysis, injection heroin use (Adjusted Hazard Ratio [AHR] 6.11; 95%CI 3.24–11.52), having an intimate partner who injects drugs (AHR 2.93; 95%CI 1.57–5.46), workplace violence (AHR 2.85; 95%CI 1.74–4.67), HIV seropositivity (AHR 2.69; 95%CI 1.45–5.00), and childhood abuse (AHR 1.86; 95%CI 0.99–3.49) were independently associated with initiating CM injection. Conclusions Findings underscore the gendered and social risk environment of CM injection initiation among sex workers. The strong influences of historical/workplace violence, coupled with heroin injection (known to be self-medicating for post-traumatic stress) as a primary risk pathway, emphasize the urgency of increasing access to integrated, trauma-informed addiction treatment and HIV care for marginalized women.

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An investigation of relations between crystal methamphetamine use and posttraumatic stress disorder

Cited by 22 publications

References 24 publications

Effects of oxytocin on methamphetamine-seeking exacerbated by predator odor pre-exposure in rats

Effects of oxytocin on methamphetamine-seeking exacerbated by predator odor pre-exposure in rats

Associations between parental posttraumatic stress disorder and both offspring internalizing problems and parental aggression within the National Comorbidity Survey-Replication

Violence, trauma and living with HIV: Longitudinal predictors of initiating crystal methamphetamine injection among sex workers

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