An investigation of some factors influencing the in vitro assessment of mucoadhesion

Mortazavi, Seyed Alireza; Smart, John D.

doi:10.1016/0378-5173(94)00299-k

Cited by 103 publications

(48 citation statements)

References 17 publications

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“…Gelatin, a protein that is the main component of many soft and hard capsules, exhibited little evidence of bioadhesive behaviour. Also in accord with previous reports (Mortazavi and Smart 1995), PVAs, the hydrophilic non-ionic polymers often used as tablet coatings, were found to behave in a similar fashion to the uncoated disc control. LustreClear™, the microcrystalline cellulose/carrageenan/polyethylene oxide based coating that is marketed as a coating with an 175 'unparalleled ease of swallowing', behaved similarly in that it showed some bioadhesive properties on application to the tissue (i.e.…”

Section: Discussionsupporting

confidence: 91%

“…In accord with findings from a previous study, sodium alginate is a material that becomes bioadhesive on hydration (Mortazavi andSmart 1994, Smart 2014). In addition to exhibiting significant bioadhesion, if dislodged this material was seen to self-repair the adhesive joint by re-165 adhering at the next contact point.…”

Section: Discussionsupporting

confidence: 88%

“…some force was required to start movement) but the average work done to pull the plate across the oesophagus was not significantly different from that obtained for the uncoated glass plate. This bioadhesive behaviour may be explained in terms of the mucoadhesive component (carrageenan; Mortazavi and Smart 1995) of the coating formulation.…”

Section: Discussionmentioning

confidence: 99%

“…It is assumed that this behavior is consequent to the PEG coating being rapidly removed in an aqueous test environment. Relatively high molecular weight polytheylene oxide coatings, which have been used as mucoadhesives (Mortazavi and Smart 1995), required an initial strong detachment force to get the disc moving but adhesion ratios were similar to those of the glass-plate control. Blending the…”

mentioning

confidence: 96%

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An evaluation of the adhesion of solid oral dosage form coatings to the oesophagus

Smart

Dunkley

Tsibouklis

et al. 2015

International Journal of Pharmaceutics

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There is a requirement for the development of oral dosage forms that are adhesive and allow extended oesophageal residence time for localised therapies, or are non-adhesive for ease of 15 swallowing. This study provides an initial assessment of the in vitro oesophageal retention characteristics of several widely utilised pharmaceutical coating materials. To this end, a previously described apparatus has been used to measure the force required to pull a coated disc-shaped model tablet across a section of excised oesophageal tissue. Of the materials tested, the well-studied mucoadhesive polymer sodium alginate was found to be associated with significant oesophageal 20 adhesion properties that was capable of 'self-repairing'. Hydroxypropylmethylcellulose exhibited less pronounced bioadhesive behaviour and blending this with plasticiser or with low molecular weight polymers and surfactants did not significantly affect this. Low molecular weight water soluble polymers, were found to behave similarly to the uncoated glass control disc. Polysorbates exhibited bioadhesion behaviour that was majorly influenced by the nature of the surfactant. The insoluble 25 polymer ethylcellulose, and the relatively lipophilic surfactant sorbitan monooleate were seen to move more readily than the uncoated disc, suggesting that these may have a role as 'easy-toswallow' coatings.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 96%

See 2 more Smart Citations

An evaluation of the adhesion of solid oral dosage form coatings to the oesophagus

Smart

Dunkley

Tsibouklis

et al. 2015

International Journal of Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…To our knowledge, the first description of a completely synthetic mucosa-mimic was reported by Mortazavi and Smart (1995), who reported the adhesion of tablets to rat intestinal mucosa and PVC 285 strips. A correlation was found between the work of adhesion measured on mucosa and PVC, and it was suggested that the PVC provides a substrate on which to measure general adhesive properties, which appeared to dominate mucoadhesion in this case.…”

Section: Synthetic Mucosa-mimicsmentioning

confidence: 99%

Mucoadhesion and mucosa-mimetic materials—A mini-review

Cook

Khutoryanskiy

2015

International Journal of Pharmaceutics

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Mucoadhesion describes an attractive interaction between dosage form and mucosal membrane.The evaluation of mucoadhesive excipients often requires the use of ex vivo mucosal tissues taken 15 from laboratory animals. These can be difficult to source, highly heterogeneous, and require the use of animal products. Thus, from both a user-convenience and ethical point-of-view, it is desirable to produce a synthetic alternative to these tissues -a mucosa-mimetic material. In this mini-review, the use of alternative materials to test the performance of mucoadhesives is reviewed and discussed. There is a surprising prevalence of the use of mucosa-mimics in the literature, which 20 hitherto has not been compiled and compared.

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Theories of Mucoadhesion

Smart

2014

Mucoadhesive Materials and Drug Delivery Systems

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An investigation of some factors influencing the in vitro assessment of mucoadhesion

Cited by 103 publications

References 17 publications

An evaluation of the adhesion of solid oral dosage form coatings to the oesophagus

An evaluation of the adhesion of solid oral dosage form coatings to the oesophagus

Mucoadhesion and mucosa-mimetic materials—A mini-review

Theories of Mucoadhesion

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