An investigation of the colony-forming capacity of bone marrow in aplastic anemia over an extended period.

3 different methods, (1) assays of CFU‐Cs and CFU‐Es, (2) responsiveness of CFU‐Cs and CFU‐Es to low doses of CSF and ESF, respectively and (3) effects of ALG on CFU‐C colony formation in vitro, were used to evaluate the quantitative and qualitative defects of stem cells in 28 patients with aplastic anaemia. Some patients with aplastic anaemia who had attained complete remission several years previously, exhibited severely depressed in vitro CFU‐C colony formation. This suggests that the defect persists for a long time after clinical complete remission. Residual marrow CFU‐Cs and CFU‐Es did not have defective responses to the humoral stimulating factors, CSF and ESF. No patient showed a rise of colony number after treatment with ALG in vitro.

show abstract

Quantitative and Qualitative Analysis of Stem Cells of Patients with Aplastic Anaemia

Yoshida

Miura

Takahashi

et al. 1983

Scandinavian Journal of Haematology

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

An investigation of the colony-forming capacity of bone marrow in aplastic anemia over an extended period.

Cited by 1 publication

References 3 publications

Quantitative and Qualitative Analysis of Stem Cells of Patients with Aplastic Anaemia

Quantitative and Qualitative Analysis of Stem Cells of Patients with Aplastic Anaemia

Contact Info

Product

Resources

About