An Investigation of the Effect of Catecholamines and Glucocorticoids on the Growth and Pathogenicity of Campylobacter jejuni

Truccollo, Brendha; Whyte, Paul; Bolton, Declan

doi:10.3390/pathogens9070555

Cited by 12 publications

(7 citation statements)

References 45 publications

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“…as well as Campylobacter spp. ( Hoffman et al, 1979 ; Cogan et al, 2007 ; Pullinger et al, 2010 ; Bearson, 2016 ; Hiller et al, 2019 ; Liu and Lyte, 2020 ; Truccollo et al, 2020 ).…”

Section: Microbial Endocrinology: How Evolved Intersections Of Microbiology and Neurobiology Matter To Poultry Well-being Susceptibility mentioning

confidence: 99%

Informal nutrition symposium: leveraging the microbiome (and the metabolome) for poultry production

et al. 2022

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Knowledge of gut microbiology of poultry has advanced from a limited ability to culture relatively few microbial species, to attempting to understand the complex interactions between the bird and its microbiome. The Informal Nutrition Symposium 2021 was intended to help poultry scientists to make sense of the implications of the vast amounts of information being generated by researchers. This paper represents a compilation of the talks given at the symposium by leading international researchers in this field. The symposium began with an overview of the historical developments in the field of intestinal microbiology and microbiome research in poultry. Next, the systemic effects of the microbiome on health in the context of the interplay between the intestinal microbiota and the immune system were presented. Because the microbiome and the host communicate and influence each other, the novel field of kinomics (the study of protein phosphorylation) as used in the study of the poultry microbiome was discussed. Protein phosphorylation is a rapid response to the complex of signals among the microbiome, intestinal lumen metabolites, and the host. Then, a description of why an understanding of the role of microbial endocrinology in poultry production can lead to new understanding of the mechanisms by which the gut microbiota and the host can interact in defined mechanisms that ultimately determine health, pathogenesis of infectious disease, and behavior was given. Finally, a view forward was presented underscoring the importance of understanding mechanisms in microbiomes in other organ systems and other species. Additionally, the importance of the development of new -omics platforms and data management tools to more completely understand host microbiomes was stressed.

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“…as well as Campylobacter spp. ( Hoffman et al, 1979 ; Cogan et al, 2007 ; Pullinger et al, 2010 ; Bearson, 2016 ; Hiller et al, 2019 ; Liu and Lyte, 2020 ; Truccollo et al, 2020 ).…”

Section: Microbial Endocrinology: How Evolved Intersections Of Microbiology and Neurobiology Matter To Poultry Well-being Susceptibility mentioning

confidence: 99%

Informal nutrition symposium: leveraging the microbiome (and the metabolome) for poultry production

et al. 2022

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“…Other neurochemicals along with serotonin have been documented in the broiler chicken intestinal track with their levels being altered during a stressed condition ( Dennis, 2009 ; Lyte et al, 2022 ). The systemic circulation of neurochemicals in chickens has been found to affect general physiology ( Denbow et al, 1983 ; Chapman et al, 2008 ) and the immune system ( Borsoi et al, 2015 ), as well as the gut and growth of different bacterial species including pathogens ( Lyte and Ernst, 1992 ; Bailey et al, 1999 ; Freestone et al, 2008 ; Truccollo et al, 2020 ; Lyte et al, 2021a ). Gut microbiota are furthermore known to produce and stimulate host neurotransmitter synthesis, with these effects found to ultimately influence host physiology and behavior ( Beaver and Wostmann, 1962 ; Reigstad et al, 2015 ; Van Staaveren et al, 2021 ).…”

Section: Introduction To the Chicken Gut-microbiome-brain Axismentioning

confidence: 99%

Connecting gut microbiomes and short chain fatty acids with the serotonergic system and behavior in Gallus gallus and other avian species

Jadhav

Han²,

Fasina³

et al. 2022

Front. Physiol.

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The chicken gastrointestinal tract has a diverse microbial community. There is increasing evidence for how this gut microbiome affects specific molecular pathways and the overall physiology, nervous system and behavior of the chicken host organism due to a growing number of studies investigating conditions such as host diet, antibiotics, probiotics, and germ-free and germ-reduced models. Systems-level investigations have revealed a network of microbiome-related interactions between the gut and state of health and behavior in chickens and other animals. While some microbial symbionts are crucial for maintaining stability and normal host physiology, there can also be dysbiosis, disruptions to nutrient flow, and other outcomes of dysregulation and disease. Likewise, alteration of the gut microbiome is found for chickens exhibiting differences in feather pecking (FP) behavior and this alteration is suspected to be responsible for behavioral change. In chickens and other organisms, serotonin is a chief neuromodulator that links gut microbes to the host brain as microbes modulate the serotonin secreted by the host’s own intestinal enterochromaffin cells which can stimulate the central nervous system via the vagus nerve. A substantial part of the serotonergic network is conserved across birds and mammals. Broader investigations of multiple species and subsequent cross-comparisons may help to explore general functionality of this ancient system and its increasingly apparent central role in the gut-brain axis of vertebrates. Dysfunctional behavioral phenotypes from the serotonergic system moreover occur in both birds and mammals with, for example, FP in chickens and depression in humans. Recent studies of the intestine as a major site of serotonin synthesis have been identifying routes by which gut microbial metabolites regulate the chicken serotonergic system. This review in particular highlights the influence of gut microbial metabolite short chain fatty acids (SCFAs) on the serotonergic system. The role of SCFAs in physiological and brain disorders may be considerable because of their ability to cross intestinal as well as the blood-brain barriers, leading to influences on the serotonergic system via binding to receptors and epigenetic modulations. Examinations of these mechanisms may translate into a more general understanding of serotonergic system development within chickens and other avians.

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“…Previous studies on catecholamines have primarily examined microbiota interactions in the human gut (Eisenhofer et al 1997; Freestone et al 2008; Zhou, Hank Simms, and Wang 2004). Some studies have investigated pathogen colonization as norepinephrine and other catecholamines regulate several microbial functions relating to pathogenicity (Chen et al 2003; Cogan et al 2007; Nakano et al 2007; Truccollo, Whyte, and Bolton 2020). L-norepinephrine (L-NE), a typical catecholamine, is a stress hormone that regulates crucial phenotypes for pathogen infections such as motility, growth, adhesion, biofilm formation, and virulence (Bansal et al 2007; Gao et al 2019; Sandrini et al 2014; Sarkodie et al 2019).…”

Section: Introductionmentioning

confidence: 99%

L-norepinephrine induces ROS formation but alters microbial community composition by altering cellular metabolism

Bains

Dahal

Manna

et al. 2022

Preprint

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Catecholamines, such as L-norepinephrine (L-NE), are naturally present in the human gut and are discharged into the sewage. The bioactivity of L-NE can significantly alter the speciation and function of the microbial community by stimulating bacterial growth and producing H2O2. The accompanying changes in intracellular metabolism could significantly impact biological wastewater treatment processes, but they have remained unexplored. We investigate the alterations by L-NE and two other Catecholamines (Dopamine, and L-Dopa) to microbial consortia sourced from a dairy farm settling pond (FS) and the activated sludge of a municipal wastewater treatment plant (MS). We contrast the effect of the catecholamines on these mixed microbial communities with dextrose, a readily degradable substrate, and elevated levels of intracellular H2O2 through high dissolved oxygen (HDO) perturbations and exogenous applications of paraquat (PQ) and hydrogen peroxide (H2O2). The microbial community composition in different catecholamines was similar to the Dextrose treatment. However, there were significant changes in the PQ and H2O2 supplemented systems. In addition, the functional potential of the microbial communities with catecholamines and Dextrose were similar and provided insight into metabolic shifts from the control systems. While exogenous H2O2 increased the abundance of Rhodocyclaceae, Flavobacteriaceae and Chitinophagaceae and others, L-NE paralleled dextrose by increasing Pseudomonadaceae, Moraxellaceae, and Sphingobacteriaceae in the microbial consortia. A number of protein functions related to oxidoreductase, peroxidase, and catalase activities, ATP and FAD/FADH2 binding, nitrate reductase, and glutamate-ammonia ligase activity were differentially expressed by L-NE over dextrose, but many of the ROS-scavenging functions were overexpressed in the exogenous H2O2 treatment over L-NE. A proteome-constrained flux balance analysis showed that in comparison to dextrose, L-NE increased the fluxes of gluconeogenesis, glycolysis, oxidative stress metabolism, and glutamate metabolism. L-NE increases stress tolerance and microbial growth by upregulating the activities of oxidative stress mitigating enzymes (catalase and thioredoxin) and nitrogen assimilation activities (glutamine formation).

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An Investigation of the Effect of Catecholamines and Glucocorticoids on the Growth and Pathogenicity of Campylobacter jejuni

Cited by 12 publications

References 45 publications

Informal nutrition symposium: leveraging the microbiome (and the metabolome) for poultry production

Informal nutrition symposium: leveraging the microbiome (and the metabolome) for poultry production

Connecting gut microbiomes and short chain fatty acids with the serotonergic system and behavior in Gallus gallus and other avian species

L-norepinephrine induces ROS formation but alters microbial community composition by altering cellular metabolism

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