An investigation of the effect of the punch velocity on the compaction properties of ibuprofen

Marshall, P.V.; York, Peter; Maclaine, J.Q.

doi:10.1016/0032-5910(93)87009-d

Cited by 44 publications

(18 citation statements)

References 19 publications

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“…Furthermore, Marshall et al (1993) had previously studied the effect of punch velocity on the densification mechanism of ibuprofen [45]. The results of that study showed a compression-dwell time dependency relationship which is a characteristic of plastic deforming materials and not of fragmenting materials.…”

Section: Resultsmentioning

confidence: 97%

Evidence-Based Nanoscopic and Molecular Framework for Excipient Functionality in Compressed Orally Disintegrating Tablets

et al. 2014

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The work investigates the adhesive/cohesive molecular and physical interactions together with nanoscopic features of commonly used orally disintegrating tablet (ODT) excipients microcrystalline cellulose (MCC) and D-mannitol. This helps to elucidate the underlying physico-chemical and mechanical mechanisms responsible for powder densification and optimum product functionality. Atomic force microscopy (AFM) contact mode analysis was performed to measure nano-adhesion forces and surface energies between excipient-drug particles (6-10 different particles per each pair). Moreover, surface topography images (100 nm2–10 µm2) and roughness data were acquired from AFM tapping mode. AFM data were related to ODT macro/microscopic properties obtained from SEM, FTIR, XRD, thermal analysis using DSC and TGA, disintegration testing, Heckel and tabletability profiles. The study results showed a good association between the adhesive molecular and physical forces of paired particles and the resultant densification mechanisms responsible for mechanical strength of tablets. MCC micro roughness was 3 times that of D-mannitol which explains the high hardness of MCC ODTs due to mechanical interlocking. Hydrogen bonding between MCC particles could not be established from both AFM and FTIR solid state investigation. On the contrary, D-mannitol produced fragile ODTs due to fragmentation of surface crystallites during compression attained from its weak crystal structure. Furthermore, AFM analysis has shown the presence of extensive micro fibril structures inhabiting nano pores which further supports the use of MCC as a disintegrant. Overall, excipients (and model drugs) showed mechanistic behaviour on the nano/micro scale that could be related to the functionality of materials on the macro scale.

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Section: Resultsmentioning

confidence: 97%

Evidence-Based Nanoscopic and Molecular Framework for Excipient Functionality in Compressed Orally Disintegrating Tablets

et al. 2014

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“…For many years, the rate of compaction has been known to have an effect on the compactability of materials (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Time dependence is related to the consolidation mechanism of the powder being compacted.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Compression and Decompression Speed on the Mechanical Strength of Compacts

Ruegger

Çelik²

2000

Pharmaceutical Development and Technology

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The purpose of this work was to investigate the effect of punch speed on the compaction properties of pharmaceutical powders; in particular, to separate out differences between the effect of the compression and decompression events. Tablets were prepared using an integrated compaction research system. Various "sawtooth" punch profiles were followed to compare the effects of different punch speeds on the crushing strength of the resulting tablets. The loading and unloading speeds were varied independently of one another. In general, when the compression speed was equal to the decompression speed, the tablet crushing strength was observed to decrease as the punch velocity increased. When the compression speed was greater than or less than the decompression speed, the results varied, depending on the material undergoing compaction. Reduction of the unloading speed from 300 to 10 mm/sec for pregelatinized starch and microcrystalline cellulose produced a significant increase in crushing strength, whereas no significant increase in crushing strength was observed until the loading speed was reduced to 10 mm/sec. Reduction of the unloading speed had a similar effect on the direct compression (DC) ibuprofen, however, even greater improvement in the crushing strength was observed when the loading speed was reduced. No improvement in the DC acetaminophen tablets was observed when the unloading speed was reduced, however, a significant increase in crushing strength was produced when the rate of loading was reduced. This work showed that the strength of tablets can be improved and some tableting problems such as capping can be minimized or prevented by modifying the rates of loading/unloading.

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“…In extreme cases (e.g. paracetamol and ibuprofen), higher punch speeds can lead to capping and lamination (Garr & Rubinstein 1991 ;Marshall et al 1993). The addition of plastically deforming microcrystalline cellulose or brittle di-calcium phosphate reduced the capping tendency of paracetamol compacts (Garr & Rubinstein 1991).…”

Section: Mechanical Properties Of the Bulk Materialsmentioning

confidence: 99%

Predictive and correlative techniques for the design, optimisation and manufacture of solid dosage forms

Hardy

Cook

2003

Journal of Pharmacy and Pharmacology

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There is much interest in predicting the properties of pharmaceutical dosage forms from the properties of the raw materials they contain. Achieving this with reasonable accuracy would aid the faster development and manufacture of dosage forms. A variety of approaches to prediction or correlation of properties are reviewed. These approaches have variable accuracy, with no single technique yet able to provide an accurate prediction of the overall properties of the dosage form. However, there have been some successes in predicting trends within a formulation series based on the physicochemical and mechanical properties of raw materials, predicting process scale-up through mechanical characterisation of materials and predicting product characteristics by process monitoring. Advances in information technology have increased predictive capability and accuracy by facilitating the analysis of complex multivariate data, mapping formulation characteristics and capturing past knowledge and experience.

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An investigation of the effect of the punch velocity on the compaction properties of ibuprofen

Cited by 44 publications

References 19 publications

Evidence-Based Nanoscopic and Molecular Framework for Excipient Functionality in Compressed Orally Disintegrating Tablets

Evidence-Based Nanoscopic and Molecular Framework for Excipient Functionality in Compressed Orally Disintegrating Tablets

The Effect of Compression and Decompression Speed on the Mechanical Strength of Compacts

Predictive and correlative techniques for the design, optimisation and manufacture of solid dosage forms

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