An investigation of the effects of FGFR2 and B7-H4 polymorphisms in breast cancer

Özgöz, Asuman; Şamlı, Hale; Öztürk, Kuyaş Hekimler; Orhan, Bülent; İçduygu, Fadime Mutlu; Aktepe, Fatma; İmirzalıoğlu, Necat

doi:10.4103/0973-1482.114434

Cited by 8 publications

(5 citation statements)

References 30 publications

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“…The study of Özgöz et al showed that, although statistically not significant (P > 0.05), the AG genotype of rs10754339 and the G allele frequency were higher in the breast cancer case group than the control group, and their study showed no association with the GG genotype (20). These results were compatible with the study of Zhang et al (19).…”

Section: Discussionsupporting

confidence: 82%

“…Again in the study of Zhang et al (19), the B7-H4 rs3738414 AA genotype and A allele were supposed to have a protective role in breast cancer, but in the study of Özgöz et al, this result was not verified, and in contrast, the GG genotype frequency was lower (20). In our study the rs3738414 AG genotype frequency was lower in the cancer case group than in the control group (P < 0.05), so the rs3738414 AG genotype may be protective in bladder cancer.…”

Section: Discussionmentioning

confidence: 90%

“…Thus, it may be thought that the rs10754339 AA genotype is associated with bladder cancer rather than breast cancer. The rs10801935 CC genotype frequency in the breast cancer case group was lower than in the control group in the studies of both Zhang et al and Özgöz et al (19,20). Zhang et al thought that the rs10801935 CC genotype may probably be protective in breast cancer patients (19).…”

Section: Discussionmentioning

confidence: 94%

“…This was the first polymorphism study to report an association between B7-H4 polymorphism and the risk of cancer (19). The second B7-H4 polymorphism study in cancer, performed by Özgöz et al, was also in breast cancer (20), and to our knowledge there is no other polymorphism study, neither in breast cancer nor in any other types of cancers. Therefore, our study is the first B7-H4 polymorphism study reporting an association between B7-H4 polymorphism and the risk of bladder cancer.…”

Section: Introductionmentioning

confidence: 99%

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Association of B7-H4 gene polymorphisms in urothelial bladder cancer

Özgöz¹,

Samli²,

Dinçel³

et al. 2017

Turk J Med Sci

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Background/aim: We aimed to study polymorphisms of the B7-H4 gene in order to evaluate a possible association in urothelial carcinoma, as it is highly expressed in cancer tissues. Materials and methods:In this study B7-H4 gene rs10754339, rs10801935, and rs3738414 SNPs were studied by PCR-RFLP method in paraffin-embedded tumor specimens from 62 urothelial carcinoma patients and in a control group including 30 patients without bladder cancer. Results:We detected that the rs10754339 polymorphism was more frequent in the cancer patients when compared with the control group (P < 0.05). Only the rs3738414 polymorphism showed a statistically significant difference in frequency between pathologic diagnostic groups. Conclusion:The rs10754339 AA genotype distribution was found to have a higher frequency whereas the rs3738414 AG genotype distribution was lower in the bladder cancer group (P < 0.05). None of the genotype distributions showed a significant difference from the control group for the rs10801935 polymorphism. We conclude that B7-H4 has the potential to be a useful prognostic marker in urothelial carcinoma.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of B7-H4 gene polymorphisms in urothelial bladder cancer

Özgöz¹,

Samli²,

Dinçel³

et al. 2017

Turk J Med Sci

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“…B7-H4, which is a novel B7 ligand that possibly acts as a negative regulatory factor in the T cell-mediated immune response, [ 20 ] is aberrantly expressed in some tumor tissues (such as breast, [ 8 , 21 ] urothelial bladder , [ 22 ] ovarian, [ 23 , 24 ] cervical, [ 25 ] lung, [ 26 ] pancreatic, [ 27 ] renal cell, [ 28 ] and gastric cancers [ 9 , 29 ] ). So, it suggests that these molecules might be new tumor diagnostic and prognostic molecular biomarkers.…”

Section: Discussionmentioning

confidence: 99%

The prognostic value of B7-H4 in pancreatic cancer

Chen

Luan²,

Yuan³

et al. 2018

Medicine

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Background:There were many reports suggesting that different kinds of tumors can express B7-H4; however, the prognostic value in cancer was still unclearly. Therefore, we conducted a meta-analysis to investigate the relationship between overexpression of B7-H4 with the prognostic value in pancreatic cancer patients.Materials and Methods:The Pubmed, Embase, Cochrane Library, Ovid, Web of Science, and Chinese research database (including CBM, CNKI, and WAN FANG) were searched for related literature published until October 12, 2017. The pooled odds ratios (ORs) and/or pooled hazard ratios (HRs) for clinical pathological factors and overall survival (OS) were calculated and analyzed using Stata software. To assess whether an individual study had an impact on the result, sensitivity analysis was performed for all included individual studies using the fixed-effects model. Publication bias was evaluated using Egger's and Begg's tests.Results:Data from 6 observational studies including 442 patients were summarized in this meta-analysis, and each study was eligible for inclusion based on included and exclude criteria. The pooled results indicated that the B7-H4 overexpression could predict the presentation of lymph node metastasis (OR = 3.94, 95% CI: 1.22–12.66, P = .022), advanced TNM stage (T = the extent of the primary tumor, N = regional lymph nodes, M = distant metastases) (III+IV vs I+II; OR = 7.63, 95% CI: 2.46–23.66, P < .001), and the poor OS (HR = 3.00, 95%CI = 2.20–4.10, P < .001) in PC patients.Conclusions:This study reveals that high expression of B7-H4 is an unfavorable prognostic factor for patients with pancreatic cancer. These results may guide the clinical management of this patient population.

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Variants of FGFR2 and their associations with breast cancer risk: a HUGE systematic review and meta-analysis

Cui

Wang

et al. 2016

Breast Cancer Res Treat

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Extensive epidemiological studies have demonstrated that there are associations between variants in intron 2 of FGFR2 and the breast cancer risk in various populations; however, the relationships are not yet conclusively established. To comprehensively review the epidemiological studies showing associations between the variants of FGFR2 and the breast cancer risk, and to establish correlations via a meta-analysis. The PubMed and MEDLINE databases were searched for eligible studies. The associations between the variants and breast cancer risk were evaluated using a random-effects model. The heterogeneity among the studies and the potential publication bias were also evaluated. Fifty-three studies with a total of 121,740 cases and 198,549 controls have examined the associations between 23 variants in intron 2 of FGFR2 and the breast cancer risk. The relationships for the 10 most frequently evaluated variants-rs1078806, rs11200014, rs1219648, rs2420946, rs2981578, rs2981579, rs2981582, rs3135718, rs10736303, and rs3750817-were synthesized based on a meta-analysis. Interestingly, we found that all 10 variants were significantly associated with the risk of breast cancer. In studies stratified by ethnicity, we found that the associations were more notable in Caucasians and Asians compared to Africans. Similar pooled results were found in population-based and hospital-based case-control studies and in studies with small and large sample sizes. FGFR2 is a breast cancer susceptibility gene, and various variants of FGFR2 are significantly associated with the breast cancer risk. However, the biological mechanisms underlying the associations need to be elucidated in future studies.

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An investigation of the effects of FGFR2 and B7-H4 polymorphisms in breast cancer

Abstract: Larger scale studies are necessary to determine the prevalence of these polymorphisms and association with breast cancer in Turkish community, as this study is the first study performed.

Cited by 8 publications

References 30 publications

Association of B7-H4 gene polymorphisms in urothelial bladder cancer

Association of B7-H4 gene polymorphisms in urothelial bladder cancer

The prognostic value of B7-H4 in pancreatic cancer

Variants of FGFR2 and their associations with breast cancer risk: a HUGE systematic review and meta-analysis

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