Fengyun-4B (FY-4B) is the first operational satellite from China’s latest generation of geostationary meteorological satellites. It is equipped with the Geostationary Interferometric Infrared Sounder (GIIRS), which is able to obtain highly accurate atmospheric temperature and humidity profiles through hyperspectral detection in long- and mid-wave infrared spectral bands. In this study, the accuracy of the FY-4B/GIIRS temperature and humidity profile retrievals over two months is evaluated using radiosonde observations and ERA5 reanalysis data. We go a step further to investigate the impact of the satellite retrievals on assimilation and forecasts for Typhoons Chaba and Ma-on in 2022. Results reveal that the root-mean-square difference (RMSD) for the FY-4B/GIIRS temperature and humidity profile retrievals were within 1 K and 1.5 g/kg, respectively, demonstrating high overall accuracy. Moreover, assimilating temperature and humidity profiles from FY-4B/GIIRS positively impacts model analysis and prediction, improving typhoon track and intensity forecasts. Additionally, improvements have been discovered in predicting precipitation, particularly with high-magnitude rainfall events.