An Investigation of the Growth Inhibitory Capacity of Several Medicinal Plants From Iran on Tumor Cell Lines

Esmaeilbeig, Maryam; Kouhpayeh, Shirin; Amirghofran, Zahra

doi:10.17795/ijcp-4032

Cited by 43 publications

(21 citation statements)

References 28 publications

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“…In a study accomplished by Esmaeilbeig et al, it was reported that IC50 of Cichorium intybus extract on Jurkat cell line was 138µg/mL after 48 hours and they also stated that Chicorium intybus extract could decrease the cell viability in Hela (Cervical Epitheloid Carcinoma) and Fen (Bladder Carcinoma) cell lines after considered treatment (18).…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effects of Cichorium Intybus Root Extract on the Proliferation and Lipogenesis of the SKBR3 Cells

et al. 2018

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Background: Fatty acid synthase (FASN) is a key enzyme in de novo lipogenesis pathway. FASN overexpression is a common feature of many human cancers like breast cancer. Furthermore, FASN expression in HER2 -positive cell lines like SKBR3 is more than other cell lines, such as MCF -7, which are not HER2 -positive. Cichorium intybus is a medicinal herb and methanolic extract of this plant significantly suppressed cell viability and growth in some cancer cells. Objectives: In this study, we aimed at investigating the effect of methanolic extract of Cichorium intybus on the FASN expression and, therefore, lipogenesis pathway in human breast cancer SKBR3 cell line. Methods:We assessed the cytotoxicity effect of Chicorium intybus on the cell viability of SKBR3 cells, using MTT assay. In addition, apoptosis rate was assessed by annexinV/PI flow cytometry. Finally, Real time q -PCR was used for the analysis of FASN gene expression. Results:The results showed that the methanolic extract of Cichorium intybus caused a dose -dependent decrease in the cell viability of SKBR3 cells. Additionally, the treatment of confluent SKBR3 cells with extract led to reduced FASN expression at mRNA level. Conclusions: These results suggest that Chicorium intybus not only inhibits cell viability in a dose -dependent manner, but also presumably inhibits lipogenesis by markedly decreased FASN expression as a key lipogenic enzyme.

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Section: Discussionmentioning

confidence: 99%

Inhibitory Effects of Cichorium Intybus Root Extract on the Proliferation and Lipogenesis of the SKBR3 Cells

et al. 2018

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“…The detected antioxidant activity encouraged the use of this plant for its antioxidant properties in food industries and in cosmetic and pharmaceutical preparations. The results evidenced strong cytotoxicity against HT-29 and HepG-2 cell lines and interesting apoptosis induction ability; the authors suggested further studies in this field [35]. Jassbi et al (2016) [32] tested the cytotoxic activity, against three human cancer cell lines (LS180, MCF-7, and MOLT-4), of dichloromethane and methanol extracts of Anthemis mirheydari, an endemic plant from Iran.…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…At the same concentration, these extracts inhibited the K562 cell line with more than 50% of inhibition[36]. Further studies are needed to identify the main active compounds.Hamzeloo-Moghadam et al (2015)[35] tested the cytotoxic activity and the apoptosis induction activity of different fractions obtained by methanolic extract of Hypericum scabrum leaves. The plant was collected from Alborz province, Iran.…”

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confidence: 99%

Iranian Medicinal Plants: From Ethnomedicine to Actual Studies

et al. 2020

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Iran has a rich and diverse cultural heritage, consisting of a complex traditional medicine deeply rooted in the history of the territory that goes back to the Assyrian and Babylonian civilizations. The ethnomedical practices that can be identifiable nowadays derive from the experience of local people who have developed remedies against a wide range of diseases handing down the knowledge from generation to generation over the millennia. Traditional medicine practices represent an important source of inspiration in the process of the development of new drugs and therapeutic strategies. In this context, it is useful to determine the state of the art of ethnomedical studies, concerning the Iranian territory, and of scientific studies on plants used in traditional Iranian medicine. Data regarding 245 plants used in Iranian ethnomedical practices and scientific studies conducted on 89 plants collected in the Iranian territory have been reported. All of the scientific studies here reported draw inspiration from traditional medicine. The World Health Organization (WHO) has repeatedly called for an intensification of the scientific validation processes of traditional medicines intended as an important contribution to public health in various parts of the world. The process of study and validation of Iranian ethnomedical practices appears to be at an early stage.

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“…5 Fruits and veggies are the primary source of antioxidants' vitamins, making these foods essential to human health. 6 Esmaeil beiget al 7 believes that safe, nontoxic origin of herbs and plants have valuable sources for novel anti-cancer drugs. According to Bauman,8 in fruits, there are important nutrient besides other vitamins, minerals, flavonoids and phytochemicals, which have been reported as a good contributing factor to the health.In addition, epidemiological studies, including experiments performed on animal models and investigations on humans have proven that consumption of a diet rich in vegetables and fruits is associated with a low risk of contracting some diseases, including cardiovascular diseases and cancers.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity Effect and Morphological Study of Different Duku(Lansium domesticum corr.) Extract towards Human Colorectal Adenocarcinoma Cells Line (HT-29)

Rohin¹,

Noratiqah²,

Ridzwan³

et al. 2017

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Context:Lansium domesticum corr. is a member of the family Meliaceae, and known locally as duku and has been used traditionally in the prevention and treatment of various illness. Aim: To study the cytotoxic effect and morphological changes of human colorectal adenocarcinoma cells (HT-29) treated with different duku (Lansium domesticum corr.) extracts. Methods: The L.domesticum corr. fruit extracts were processed involving three different solvents; methanol, ethanol and ethyl acetate. HT-29 cell lines were treated with different concentrations of L. domesticum corr. (0-100 µg/ml) extracts for a total of 24, 48 and 72 hours. Cytotoxicity of cells line was determined by using MTT assay as per IC 50 values. Results: Methanol extract of L. domesticum corr. showed IC 50 value at 6.79 ± 0.00 µg/ml and 50.0 ± 0.00 µg/ml respective, while ethyl acetate extract of L. domesticum corr. reached IC 50 value at 86.00 ± 0.08 µg/ml, and 96.0 ± 0.12 µg/ml. There was no IC 50 value of ethanol extract from L.domesticum corr. Only methanol extract showed toxicity towards HT-29 cells line. Conclusion: To the best of our knowledge, this is the first repeat the exploring the effect of duku (L. domesticum corr.) extract on HT-29 cells line.

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An Investigation of the Growth Inhibitory Capacity of Several Medicinal Plants From Iran on Tumor Cell Lines

Cited by 43 publications

References 28 publications

Inhibitory Effects of Cichorium Intybus Root Extract on the Proliferation and Lipogenesis of the SKBR3 Cells

Inhibitory Effects of Cichorium Intybus Root Extract on the Proliferation and Lipogenesis of the SKBR3 Cells

Iranian Medicinal Plants: From Ethnomedicine to Actual Studies

Cytotoxicity Effect and Morphological Study of Different Duku(Lansium domesticum corr.) Extract towards Human Colorectal Adenocarcinoma Cells Line (HT-29)

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