An investigation of the physics mechanism based on DNA damage produced by protons and alpha particles in a realistic DNA model

Shamshiri, Pezhman; Forozani, Ghasem; Zabihi, Azam

doi:10.1016/j.nimb.2019.04.086

Cited by 6 publications

(2 citation statements)

References 38 publications

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“…Different studies have used different methods to calculate LET values. Some studies have calculated LET values at the center of the cell (38)(39)(40) or in the cell entrance (41) . Figure 2 shows that an increase in energy leads to a decrease in the LET.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the direct DNA damages irradiated by protons of different energies using geant4-DNA toolkit

et al. 2020

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Background:The total yields of direct Single-Strand Breaks (SSBs) and Double -Strand Breaks (DSBs) in proton energies varying from 0.1 to 40 MeV were calculated. While other studies in this field have not used protons with energy less than 0.5 MeV, our results show interesting and complicated behavior of these protons. Materials and Methods: The simulation has been done using the Geant4-DNA toolkit. An atomic model of DNA geometry was simulated. Simulations were performed with a source in the Z-axis direction at the cell nucleus entrance with protons at energies of 0.1-1 MeV in 0.1 MeV steps, 5 MeV, and 10-40 MeV in 10 MeV steps. Results: The calculated SSB yields decreased from 60.08 (GbpGy) −1 for 0.1 MeV proton energy to 49.52 (GbpGy) −1 for 0.5 MeV proton energy, and then it increased to 54.35 (GbpGy) −1 in 40 MeV. The DSB yields decreased from 4.32 (GbpGy) −1 for 0.1 MeV proton energy to 1.03 (GbpGy) −1 for 40-MeV protons. The DSB yields for energies less than 0.5 MeV was about 56%, and for the other energy levels, it was 44%. As for SSB yields, 35% of the breaks arose from protons with an energy of fewer than 0.5 MeV and 65% from higher energies. Conclusion: It was found that the proton ranges with an energy less than 0.5 MeV are smaller than the cell size (10 μm), and 100% of the energy is deposited in the cell region. Then protons with these energies are the best choice to increase the number of DSBs.

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Section: Discussionmentioning

confidence: 99%

Investigation of the direct DNA damages irradiated by protons of different energies using geant4-DNA toolkit

et al. 2020

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“…Tajik et al [5] used a Monte Carlo simulation to calculate the direct effects of gamma rays on various DNA structures. Shamshiri et al [6] studied the direct effect of monoenergetic protons and alpha particles on DNA molecules using Geant4 toolkit. Recently, Al-Buriahi et al [7] studied the gamma, neutron, and charged particle interaction with DNA nucleobases using the FLUKA code.…”

Section: Introductionmentioning

confidence: 99%

Attenuation Properties of DNA Nucleobases Against Nuclear Radiation Using EpiXS, Py-MLBUF, and NGCal Software

Hiremath,

Singh,

Patil

et al. 2024

Acta Phys. Pol. A

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In this study, the gamma and neutron interaction parameters of deoxyribonucleic acid and ribonucleic acid nucleobases such as adenine, cytosine, guanine, thymine, and uracil were estimated and compared to those of water. The present calculated mass attenuation coefficient values of deoxyribonucleic acid nucleobases were compared with available simulation code values. From the data, it is observed that guanine has the highest linear attenuation coefficient values among the nucleobases and water in the energy region from 0.015 to 15 MeV. Uracil has a higher effective atomic number and equivalent atomic number values than other nucleobases in the energy region from 0.015 to 15 MeV. Among the nucleobases, uracil has lower buildup factor values, up to 200 keV. However, up to 200 keV, uracil has higher buildup factor values than water. The mass attenuation factor values for nucleobases are listed in the following order: thymine > cytosine > adenine > uracil > guanine. It has been discovered that as the mass attenuation factor increases, the hydrogen wt% of nucleobases also increases.

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Quantitative comparison between DNA damage RBE of GdNCT and BNCT during brain tumor irradiation

Shamsabadi,

Baghani

2024

J Radioanal Nucl Chem

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An investigation of the physics mechanism based on DNA damage produced by protons and alpha particles in a realistic DNA model

Cited by 6 publications

References 38 publications

Investigation of the direct DNA damages irradiated by protons of different energies using geant4-DNA toolkit

Investigation of the direct DNA damages irradiated by protons of different energies using geant4-DNA toolkit

Attenuation Properties of DNA Nucleobases Against Nuclear Radiation Using EpiXS, Py-MLBUF, and NGCal Software

Quantitative comparison between DNA damage RBE of GdNCT and BNCT during brain tumor irradiation

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