An investigation of the potential association between retinal detachment and oral fluoroquinolones: a self-controlled case series study

Chui, Celine S L; Man, Kenneth K C; Cheng, Ching Lan; Chan, Esther W.; Lau, Wallis C.Y.; Cheng, Vcc; Wong, David; Kao, Yea Huei Yang; Wong, Ian C K

doi:10.1093/jac/dku145

Cited by 38 publications

(41 citation statements)

References 13 publications

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“…13 CDARS has been used for conducting high-quality, population-based studies. [13][14][15][16][17] A local study showed high coding accuracy in CDARS with a positive predictive value (PPV) of 90%. 18 Nonetheless, we conducted further validation on a sample of patients in this cohort to ensure the validity of our data set.…”

Section: Data Sourcementioning

confidence: 99%

Prevention of Dabigatran-Related Gastrointestinal Bleeding With Gastroprotective Agents: A Population-Based Study

et al. 2015

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Section: Data Sourcementioning

confidence: 99%

Prevention of Dabigatran-Related Gastrointestinal Bleeding With Gastroprotective Agents: A Population-Based Study

et al. 2015

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“…21,38,39 In this study, it allowed each CRAO case to serve as his/her own control, which inherently enables avoiding between-person confounding factors. 21 In addition, the SCCS design is appealing when the outcome is rare (e.g., CRAO), similar to a case-control study.…”

Section: Park Et Al Risk For Stroke and Myocardial Infarction After Craomentioning

confidence: 99%

Risk and Risk Periods for Stroke and Acute Myocardial Infarction in Patients with Central Retinal Artery Occlusion

et al. 2015

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“…CDARS has been used in previous epidemiologic studies. [16][17][18][19][20][21] Clinical practice research datalink. The CPRD contains the anonymized electronic primary care records for approximately 8.5% of the UK population with more than 5 million currently active patients and more than 13 million records dating back to 1987.…”

Section: Data Sources Clinical Data Analysis and Reporting Systemmentioning

confidence: 99%

“…The crude absolute risk for incident seizure was estimated using the method in the previous study, 16 presented as per 10,000 oral FQ prescriptions.…”

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Association between oral fluoroquinolones and seizures

Chui¹,

Chan²,

Wong³

et al. 2016

Neurology

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Objectives: The aim of this study was to investigate the association and to estimate the crude absolute risk of seizure among patients exposed to fluoroquinolones (FQs) in Hong Kong and the United Kingdom.Methods: A self-controlled case series study was conducted. Data were collected from the Hong Kong Clinical Data Analysis and Reporting System database and the Clinical Practice Research Datalink. Patients who were prescribed any oral FQ and had an incident seizure diagnosis from 2001 to 2013 were included. The risk windows were defined as pre-FQ start, FQ-exposed, and post-FQ completion. Incidence rate ratios were estimated in all risk windows and compared with baseline periods. A post hoc subgroup analysis was conducted to examine the effect of patients with a history of seizure.Results: An increased incidence rate ratio was found in the pre-FQ start periods and no association was found in the post-FQ completion periods in both databases. The crude absolute risk of an incident seizure in 10,000 oral FQ prescriptions was 0.72 (95% confidence interval 0.47-1.10) in the Clinical Data Analysis and Reporting System and 0.40 (95% confidence interval 0.30-0.54) in the Clinical Practice Research Datalink. The rate ratio during treatment was not higher than pre-FQ start periods among patients with a history of seizure, therefore the results did not raise serious concerns.Conclusions: This study does not support a causal association between the use of oral FQs and the subsequent occurrence of seizure. An increased risk before the FQ exposure period suggests that the clinical indication for which FQ was prescribed may have contributed to the development of seizure rather than the drug itself.

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An investigation of the potential association between retinal detachment and oral fluoroquinolones: a self-controlled case series study

Cited by 38 publications

References 13 publications

Prevention of Dabigatran-Related Gastrointestinal Bleeding With Gastroprotective Agents: A Population-Based Study

Prevention of Dabigatran-Related Gastrointestinal Bleeding With Gastroprotective Agents: A Population-Based Study

Risk and Risk Periods for Stroke and Acute Myocardial Infarction in Patients with Central Retinal Artery Occlusion

Association between oral fluoroquinolones and seizures

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