An Investigation of the Psychometric Properties of Illness Perception Questionnaire for Schizophrenia (IPQS) in Iran

Shokrgozar, Somayeh; Soleimani, Robabeh; Abdollahi, Elahe; Fallahi, Mahnaz; Roshandel, Mahboube; Noori, Seyyedeh Zahra Seyyed

doi:10.14704/nq.2017.15.3.1113

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…In this questionnaire, high scores are indicative of a severe condition. The reliability and Cronbach's alpha of this scale were 0.73, 0.83, and 0.79 for the subscales of positive symptoms, negative symptoms, and general disorder, respectively [23]. The SCID-1 questions were generally understandable and acceptable for Iranian people.…”

Section: Methodsmentioning

confidence: 84%

MicroRNAs and Pro-Inflammatory Cytokines as Candidate Biomarkers for Recent-Onset Psychosis

et al. 2021

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Section: Methodsmentioning

confidence: 84%

MicroRNAs and Pro-Inflammatory Cytokines as Candidate Biomarkers for Recent-Onset Psychosis

et al. 2021

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MicroRNAs and pro-inflammatory cytokines as candidate biomarkers for recent-onset psychosis

Shafiee-Kandjani,

Nezhadettehad,

Farhang

et al. 2023

BMC Psychiatry

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Background Recent studies on the schizophrenia spectrum and other psychotic disorders showed that alternation of immune system components, particularly microRNAs (miRNAs) and pro-inflammatory compounds, plays a significant role in developing the illness. The study aimed to evaluate serum expression of the miRNA-26a, miRNA-106a, and miRNA-125b as genetic factors and serum levels of IL-6, IL-1β, and TNF-α as pro-inflammatory factors in an IranianAzeri population. Methods Forty patients with recent-onset non-affective psychosis and 40 healthy people as a control group were involved. Expression levels of miRNAs and serum levels of the cytokines were measured using RT-qPCR and ELISA, respectively. T-test, receiver operating characteristics (ROC), and spearman correlation coefficient were carried out data analysis. Results Findings showed higher levels of IL-6, IL-1β, TNF-α, miR-26a, and miR-106a in the plasma of the patients’ group compared with the control. miRNA-26a showed a statistically significant higher level (p < .003) compared to the control group, with AUC = 0.84 (95% CI: 0.77 to 0.93, P < .001) and cut-off point = 0.17 in comparison to other miRNAs as mentioned above; in this regard, it might be a suggestive biomarker for schizophrenia in the early stage of the illness. Moreover, miRNAs’ expression level was not substantially associated with the level of any measured cytokines above. Conclusions miR-26a might be a suggestive biomarker for schizophrenia in the early stage of the illness. Given that the relationship between other miRNAs and cytokines is not yet well understood; accordingly, there are encouragement and support for continued research in this fascinating field.

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常人疾病观及其对医患关系的影响

Xiao-kang¹,

Tang²,

He³

et al. 2019

Adv Psychol Sci

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An Investigation of the Psychometric Properties of Illness Perception Questionnaire for Schizophrenia (IPQS) in Iran

Cited by 3 publications

References 8 publications

MicroRNAs and Pro-Inflammatory Cytokines as Candidate Biomarkers for Recent-Onset Psychosis

MicroRNAs and Pro-Inflammatory Cytokines as Candidate Biomarkers for Recent-Onset Psychosis

MicroRNAs and pro-inflammatory cytokines as candidate biomarkers for recent-onset psychosis

常人疾病观及其对医患关系的影响

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