2022
DOI: 10.1097/scs.0000000000008512
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An Investigation of the Relationship Between the Second-to-Fourth Digit Ratio and Sagittal Synostosis

Abstract: Background: The most common presentation of nonsyndromic craniosynostosis is that of the sagittal suture. Amongst this subgroup there is a significant male preponderance. Although the etiology is largely unknown, androgen exposure in utero has been suggested as a contributing factor. The second-to-fourth digit ratio (2D:4D) is a sexually dimorphic trait, reflective of the levels of androgen and estrogen exposure in utero, with a lower 2D:4D ratio associated with higher androgen exposure. This study aimed to ex… Show more

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