Powder sintering is a low-energy, net-shape processing route for many new products in the additive manufacturing space. We advance the viewpoint that for future manufacturing, alloys should be designed from materials science principles to sinter quickly at lower temperatures and with controlled final microstructures. Specifically, we illustrate the computational design of a multinary Ni-base alloy, whose chemistry permits a low-temperature solid-state sintering scheme without any pressure- or field-assistance, as well as heat-treatability after sintering. The strategy is based on sequential phase evolutions designed to occur during sintering. The reactions involve rapid reorganization of matter to full density in cycles up to just 1200°C, while conventional Ni alloys sintered in the solid-state require about ten times longer, or more than 250°C degrees higher temperature. Our approach yields an alloy that benefits from precipitation hardening, has an increased strength ~ 50% higher than solid-state processed commercial Ni alloys, and yet exhibits extensive plasticity beyond 35% uniaxial strain. The results point to a generalizable design scheme for many other alloys designed for solid-state powder processing that can enable greater value from additive manufacturing.