The paper provides a discussion on damage tolerance options applied to railway axles and factors influencing the residual lifetime as well as the required inspection interval. These comprise material properties such as the scatter of the da/dN-ΔK curve, the fatigue crack propagation threshold ΔK th and the toughness of the material. Parameters affecting axle loading such as the press fit, rotating bending, load history and mixed crack opening modes are discussed. Finally the influence of the initial crack geometry on residual lifetime is simulated.