An investigation on the mechanism of anticonvulsant action of ketamine and phencyclidine on convulsions due to cortical application of penicillin in rabbits

Sagratella, S.; Niglio, Tarcisio; Carolis, A. Scotti de

doi:10.1016/0031-6989(85)90092-x

Cited by 15 publications

(9 citation statements)

References 19 publications

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“…This finding may be explained by the kind of penicillin-induced epileptic seizure. It starts as a focal seizure and has a tendency to get generalized resembling the Grand ma1 epilepsy (18). This hypothesis is also in agreement with the idea that, hippocampal sclerosis is directly correlated with the kind of epileptic seizure, but is not correlated with the frequency and number of seizures generated.…”

Section: Resultssupporting

confidence: 88%

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Effect of penicillin‐induced epilepsy seizure on the volume of hippocampus stratum pyramidalis in rat

Unal

Akdoğan

Adıgüzel

et al. 2003

Neuroscience Res Communica

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SUMMARYExperimental epileptic models have been developed to assess the pathophysiology of epileptic seizures. We have previously shown that epileptic seizures cause significant neuronal loss in hippocampus (pO.O5). This study suggests that the loss of hippocampal neurons in penicillin-induced epilepsy seizure is not directly correlated with a volume change in the hippocampus. Furthermore, our results indicate that it is important to assess both the neuron number and the volume of the affected area using stereological methods in an epilepsy model to objectively analyze the effects of the seizure.

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Section: Resultssupporting

confidence: 88%

“…Penicillin is a well-known chemical convulsive agent (15,16) that induces experimental epileptic seizures. It has previously been shown that penicillin can induce partial seizures when it is used topically (17,18).…”

Section: Introductionmentioning

confidence: 99%

Effect of penicillin‐induced epilepsy seizure on the volume of hippocampus stratum pyramidalis in rat

Unal

Akdoğan

Adıgüzel

et al. 2003

Neuroscience Res Communica

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“…PCP also was originally introduced as a general anesthetic agent [5−7], but it was subsequently withdrawn from use in humans because of severe psychomimetic side effects [8−13]. The focus of research on PCP has shifted from its use as an anesthetic toward potential applications as a neuropharmaceutical [14,15].…”

Section: Introductionmentioning

confidence: 99%

Synthesis with Improved Yield and Study on the Analgesic Effect of 2-Methoxyphencyclidine

Ahmadi

Mahmoudi

2011

Arzneimittelforschung

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Phencyclidine (1-(1-phenylcyclohexyl)piperidine, CAS 956-90-1, PCP) has shown analgesic effects. Some of its derivatives have been synthesized and their biological properties were studied. Since a methoxy group has been added to the position 2 of the cyclohexane ring of PCP, the resulting compound is more polar than PCP. This compound was synthesized using an improved method with a higher yield. Its analgesic effect was studied using the tail-flick test on rats and was compared with that of ketamine (CAS 1867-66-9). The results showed that 2-methoxyphencyclidine increased tall-flick latencies as compared to the control group. The maximum analgesic effect of the compound occurred 5-10 min after its injection, while the effect of ketamine was observed 10-25 min after injection.

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“…One of these models is the penicillin model experimental epilepsy. Intracortical penicillin administration triggers an epileptogenic focus formation similar to focal seizures of epileptic patients 3 . Penicillin, structurally similar to GABA antagonist bicuculline which blocks the inhibitory GABA system and causes the formation of epileptic seizures 4 .…”

Section: Introductionmentioning

confidence: 99%

Proconvulsant effect of bisphenol A in penicillin induced epileptiform activity

Arslan¹,

Ağar²

2019

Cumhuriyet Medical Journal

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Epilepsy is a neurological disease characterized by seizures that can affect all age groups. Experimental epilepsy models have been used in order to prevent and treat epileptic seizures. Bisphenol A (BPA) is found in the plastics that are used in our daily lives and causes harmful effects on the central nervous system. In this study, we aimed to investigate the effect of BPA in the penicillin-induced epileptiform activity. Method: Male Wistar rats weighing 205 ± 220 grams were separated into 4 groups: Control (n=7), 125 μg/kg BPA (n=7), 250 μg/kg BPA (n=7) and 500 μg/kg BPA (n=7). Rats were anesthetized with urethane and were fixed to a stereotaxic device. With the stereotaxic guidance, an electrode was placed over the left somatomotor cortex and is connected to the recorder. 500 IU penicillin G was administered intracortically for induction of epileptiform activity. After 30 minutes from penicillin injection, the doses of BPA or olive oil were administered intraperitoneally, and electrocorticography recording continued for 180 minutes after drug injection. Results: BPA, at a dose of 125 μg/kg, did not significantly change either the means of spike frequency or amplitude when compared to the control group.BPA, at the doses of 250 and 500 μg/kg, showed proconvulsant activity by increasing the mean spike frequency in the 50 and 40 minutes (respectively) until the end of the experiment without changing the amplitude. Conclusions: The results of the present study provide electrophysiological evidence that BPA increases the epileptiform activity. Therefore, we suggest that epilepsy patients should avoid exposure to BPA.

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An investigation on the mechanism of anticonvulsant action of ketamine and phencyclidine on convulsions due to cortical application of penicillin in rabbits

Cited by 15 publications

References 19 publications

Effect of penicillin‐induced epilepsy seizure on the volume of hippocampus stratum pyramidalis in rat

Effect of penicillin‐induced epilepsy seizure on the volume of hippocampus stratum pyramidalis in rat

Synthesis with Improved Yield and Study on the Analgesic Effect of 2-Methoxyphencyclidine

Proconvulsant effect of bisphenol A in penicillin induced epileptiform activity

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