An Investigation on the Therapeutic Potential of Butein, A Tretrahydroxychalcone Against Human Oral Squamous Cell Carcinoma

Bordoloi, Devivasha; Monisha, Javadi; Roy, Nand Kishor; Padmavathi, Ganesan; Banik, Kishore; Harsha, Choudhary; Wang, Hong; Kumar, Alan Prem; Arfuso, Frank; Kunnumakkara, Ajaikumar B.

doi:10.31557/apjcp.2019.20.11.3437

Cited by 49 publications

(27 citation statements)

References 89 publications

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“…Various phytochemical and natural compounds obtained from different parts of plants have been a part of traditional medicine for ages and consumed for their health benefits as well as efficacy against a plethora of diseases [ [201] , [202] , [203] , [204] , [205] , [206] , [207] , [208] , [209] , [210] , [211] , [212] , [213] , [214] , [215] ].…”

Section: Anti-inflammatory Role Of Spicesmentioning

confidence: 99%

COVID-19, cytokines, inflammation, and spices: How are they related?

et al. 2021

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Background Cytokine storm is the exaggerated immune response often observed in viral infections. It is also intimately linked with the progression of COVID-19 disease as well as associated complications and mortality. Therefore, targeting the cytokine storm might help in reducing COVID-19-associated health complications. The number of COVID-associated deaths (as of January 15, 2021; https://www.worldometers.info/coronavirus/ ) in the USA is high (1199/million) as compared to countries like India is low (110/million). Although the reason behind this is not clear, spices may have some role in explaining this difference. Spices and herbs are used in different traditional medicines, especially in countries such as India to treat various chronic diseases due to their potent antioxidant and anti-inflammatory properties. Aim To evaluate the literature available on the anti-inflammatory properties of some spices which might prove beneficial in the prevention and treatment of COVID-19 associated cytokine storm. Method A detailed literature search has been conducted on PubMed for collecting information pertaining to the COVID-19; the history, origin, key structural features, and mechanism of infection of SARS-CoV-2; the repurposed drugs in use for the management of COVID-19 and the anti-inflammatory role of spices to combat COVID-19 associated cytokine storm. Key findings The literature search resulted in numerous in vitro , in vivo and clinical trials that have reported the potency of spices to exert anti-inflammatory effects by regulating crucial molecular targets for inflammation. Significance As spices are derived from Mother Nature and are inexpensive, they are relatively safer to consume. Therefore, their anti-inflammatory property can be exploited to combat the cytokine storm in COVID-19 patients. This review thus focuses on the current knowledge on the role of spices for the treatment of COVID-19 through suppression of inflammation-linked cytokine storm.

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Section: Anti-inflammatory Role Of Spicesmentioning

confidence: 99%

COVID-19, cytokines, inflammation, and spices: How are they related?

et al. 2021

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“…Zhang et al [ 200 ] found that ISL downregulated the expression of several MMPs including MMP-9 at mRNA as well as protein level. Additionally, suppression of MMP-9 expression has also been reported in butein-treated oral squamous cell carcinoma [ 102 ].…”

Section: Antiangiogenic Effects Of Chalconesmentioning

confidence: 99%

“…Butein, first isolated from the plant Oxicodendron vernicifluum, has been shown in a human oral squamous cancer cell line as an inhibitor of the phosphorylated form of NF-κB (p-p65). Moreover, butein also downregulated several NF-κB-regulated proteins such as the antiapoptotic factor survivin, COX-2, and adhesion molecule MMP-9 [ 102 ].…”

Section: Modulation Of Selected Signaling Pathwaysmentioning

confidence: 99%

Molecular Mechanisms of Antiproliferative Effects of Natural Chalcones

Michalková¹,

Mirossay²,

Gazdova³

et al. 2021

Cancers

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Although great progress has been made in the treatment of cancer, the search for new promising molecules with antitumor activity is still one of the greatest challenges in the fight against cancer due to the increasing number of new cases each year. Chalcones (1,3-diphenyl-2-propen-1-one), the precursors of flavonoid synthesis in higher plants, possess a wide spectrum of biological activities including antimicrobial, anti-inflammatory, antioxidant, and anticancer. A plethora of molecular mechanisms of action have been documented, including induction of apoptosis, autophagy, or other types of cell death, cell cycle changes, and modulation of several signaling pathways associated with cell survival or death. In addition, blockade of several steps of angiogenesis and proteasome inhibition has also been documented. This review summarizes the basic molecular mechanisms related to the antiproliferative effects of chalcones, focusing on research articles from the years January 2015–February 2021.

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“…The high incidence of OC in low resource countries is due to several customary habits such as alcohol consumption, smoking, tobacco chewing and areca nut chewing [10]. OC may also occur due to human papillomavirus (HPV) infection, poor dental care, poor hygiene and consumption of unhealthy food.…”

Section: Introductionmentioning

confidence: 99%

Targeting AKT/mTOR in Oral Cancer: Mechanisms and Advances in Clinical Trials

Harsha

Banik

Ang

et al. 2020

IJMS

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166

110

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Oral cancer (OC) is a devastating disease that takes the lives of lots of people globally every year. The current spectrum of treatment modalities does not meet the needs of the patients. The disease heterogeneity demands personalized medicine or targeted therapies. Therefore, there is an urgent need to identify potential targets for the treatment of OC. Abundant evidence has suggested that the components of the protein kinase B (AKT)/ mammalian target of rapamycin (mTOR) pathway are intrinsic factors for carcinogenesis. The AKT protein is central to the proliferation and survival of normal and cancer cells, and its downstream protein, mTOR, also plays an indispensable role in the cellular processes. The wide involvement of the AKT/mTOR pathway has been noted in oral squamous cell carcinoma (OSCC). This axis significantly regulates the various hallmarks of cancer, like proliferation, survival, angiogenesis, invasion, metastasis, autophagy, and epithelial-to-mesenchymal transition (EMT). Activated AKT/mTOR signaling is also associated with circadian signaling, chemoresistance and radio-resistance in OC cells. Several miRNAs, circRNAs and lncRNAs also modulate this pathway. The association of this axis with the process of tumorigenesis has culminated in the identification of its specific inhibitors for the prevention and treatment of OC. In this review, we discussed the significance of AKT/mTOR signaling in OC and its potential as a therapeutic target for the management of OC. This article also provided an update on several AKT/mTOR inhibitors that emerged as promising candidates for therapeutic interventions against OC/head and neck cancer (HNC) in clinical studies.

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An Investigation on the Therapeutic Potential of Butein, A Tretrahydroxychalcone Against Human Oral Squamous Cell Carcinoma

Cited by 49 publications

References 89 publications

COVID-19, cytokines, inflammation, and spices: How are they related?

COVID-19, cytokines, inflammation, and spices: How are they related?

Molecular Mechanisms of Antiproliferative Effects of Natural Chalcones

Targeting AKT/mTOR in Oral Cancer: Mechanisms and Advances in Clinical Trials

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