An Involvement of Trigeminal Mesencephalic Neurons in Regulation of Occlusal Vertical Dimension in the Guinea Pig

Zhang, W.; Kobayashi, Masayuki; Moritani, Masayuki; Masuda, Yuji; Dong, Jane; Yagi, Takakazu; Maeda, Takeyasu; Morimoto, Toshifumi

doi:10.1177/154405910308200715

Cited by 22 publications

(7 citation statements)

References 15 publications

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“…It has been repeatedly suggested that inputs from jaw muscle spindles would be involved in the physiological mechanism of OVD regulation (e.g., Yagi et al, 2003;Zhang et al, 2003). Thus, sensory feedback from the jaw muscle could be blamed for the instability and relapse of occlusal treatments.…”

Section: Discussionmentioning

confidence: 99%

“…Although some studies suggest the OVD to be strictly controlled (Yagi et al, 2003), and that this control would be exerted, at least in part, by inputs from jaw-muscle spindles (Zhang et al, 2003), we have recently demonstrated that masseter muscle spindles already start to show some degree of functional plasticity 5 days after the establishment of an increased OVD (iOVD) condition (Yabushita et al, 2005); i.e., some parameters of muscle-spindle function, particularly those related to the receptor's sensitivity, were affected by changes in OVD. In this study, we tested for the possibility of functional recovery in masseter muscle spindles following longer periods of observation after iOVD.…”

Section: Introductionmentioning

confidence: 99%

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Functional Adaptability of Jaw-muscle Spindles after Bite-raising

et al. 2006

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In a previous experiment, we found that masseter muscle spindles show functional plasticity after 5 to 15 days under increased occlusal vertical dimension (iOVD). In the present study, we hypothesized that spindle function would eventually recover if longer observation periods were allowed. Therefore, in this study we investigated changes in masseter muscle spindle function over periods of 1 day to 8 weeks. Masseter muscle-spindle responses to ramp-and-hold jaw stretches were recorded from the mesencephalic trigeminal nucleus in 35 barbiturate-anesthetized female Wistar rats. The rats were previously divided into Control and iOVD groups, and those in the iOVD group received a 2.0-mm composite resin build-up to the maxillary molars. In this condition, there were no statistically significant differences in masseter muscle spindle sensitivity between Control and iOVD in the six- and eight-week subgroups. Our results further indicate a high degree of adaptability in masseter muscle spindle function following changes in OVD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Functional Adaptability of Jaw-muscle Spindles after Bite-raising

et al. 2006

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“…The periodontal ligament not only regulates occlusal force associated with muscle spindles in the closer jaw muscles (Zhang et al 2003;Lund and Kolta 2006) but also perceives nociception mediated by free nerve endings of Aδ and C fibers, which originate from the trigeminal ganglion (Byers 1985) and project to the trigeminal spinal Vi and Vc (subnuclei interpolaris and caudalis, respectively; Sugimoto et al 1997;Watanabe et al 2002). A portion of these nociceptive fibers contain calcitonin gene-related peptide and/or galanin, whose expression is increased by experimental tooth movement (ETM; Kvinnsland and Kvinnsland 1990;Deguchi et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Orthodontic Force Facilitates Cortical Responses to Periodontal Stimulation

et al. 2015

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Somatosensory information derived from the periodontal ligaments plays a critical role in identifying the strength and direction of occlusal force. The orthodontic force needed to move a tooth often causes uncomfortable sensations, including nociception around the tooth, and disturbs somatosensory information processing. However, it has mostly remained unknown whether orthodontic treatment modulates higher brain functions, especially cerebrocortical activity. To address this issue, we first elucidated the cortical region involved in sensory processing from the periodontal ligaments and then examined how experimental tooth movement (ETM) changes neural activity in these cortical regions. We performed in vivo optical imaging to identify the cortical responses evoked by electrical stimulation of the maxillary and mandibular incisor and the first molar periodontal ligaments in the rat. In naïve rats, electrical stimulation of the mandibular periodontal ligaments initially evoked neural excitation in the rostroventral part of the primary somatosensory cortex (S1), the ventrocaudal part of the secondary somatosensory cortex (S2), and the insular oral region (IOR), whereas maxillary periodontal ligaments elicited excitation only in S2/IOR rostrodorsally adjacent to the mandibular periodontal ligament-responding region. In contrast, maximum responses to mandibular and maxillary periodontal stimulation were observed in S1 and S2/IOR, and the 2 responses nearly overlapped. One day after ETM (maxillary molar movement by Waldo's method), the maximum response to stimulation of the maxillary molar periodontal ligament induced larger and broader excitation in S2/IOR, although the initial responses were not affected. Taken together with the histologic findings of IL-1β expression and macrophage infiltration in the periodontal ligament of the ETM models, inflammation induced by ETM may play a role in the facilitation of S2/IOR activity. From the clinical viewpoints, the larger amplitude of cortical excitation may induce higher sensitivity to pain responding to nonnoxious stimuli, and enlargement of the responding area may reflect radiating pain.

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“…However, the reduction of OVD may be attributed to the total changes in the upper and lower teeth length. Zhang et al (12) reported that the tooth-grinding ability of guinea pigs after increasing their bite was impaired by the destruction of the trigeminal mesencephalic nucleus in bite-raised animals. Muscle spindle afferents of the jaw-closing muscles may be closely involved in OVD adjustment.…”

Section: Temporal Change In Ovdmentioning

confidence: 99%

Temporal change in the occlusal vertical dimension and its involvement in modulation of jaw movement in bite-reduced animals

Matoba¹,

Kanayama²,

Kato

et al. 2018

J Oral Sci

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The occlusal vertical dimension (OVD) in guinea pigs is maintained by tooth eruption and grinding. It has been reported that the experimentally raised OVD recovers to the innate OVD within a few days in guinea pigs. However, the mechanisms underlying OVD adjustment are not entirely understood. This study thus aimed to clarify whether the experimentally reduced OVD would recover. Bite-reduced guinea pigs were created by applying bilateral intermaxillary elastics for 10 days. Guinea pigs without elastics were used as a control. The OVD after removal of the elastics in the experimental group was compared with that of the control group. Jaw movement during chewing was also compared between the experimental and control groups. After removal of the elastics, the experimentally reduced OVD did not recover fully and a significant difference was observed between the experimental and control groups for up to 25 days during the recording period. The minimum closed position during chewing was significantly higher in the experimental group than in the control group, whereas the maximum open position was no different between the groups. The present findings indicated that the experimentally reduced OVD could not be fully recovered, suggesting that reduction of the OVD may have limited influence on jaw movement.

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An Involvement of Trigeminal Mesencephalic Neurons in Regulation of Occlusal Vertical Dimension in the Guinea Pig

Cited by 22 publications

References 15 publications

Functional Adaptability of Jaw-muscle Spindles after Bite-raising

Functional Adaptability of Jaw-muscle Spindles after Bite-raising

Orthodontic Force Facilitates Cortical Responses to Periodontal Stimulation

Temporal change in the occlusal vertical dimension and its involvement in modulation of jaw movement in bite-reduced animals

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