An iridoid glycoside from Cornus officinalis balances intestinal microbiome disorder and alleviates alcohol-induced liver injury

Han, Xiao; Liu, Jia; Bai, Yingfeng; Hang, Aiwu; Lu, Tu-Lin; Mao, Chunqin

doi:10.1016/j.jff.2021.104488

Cited by 13 publications

(10 citation statements)

References 47 publications

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“…It can convert alcohol into acetaldehyde, which in turn can be converted into acetic acid. However, excessive alcohol consumption may lead to the metabolic dysfunction of liver, which is characterized by higher levels of liver lipids and oxidative stress, and lower activities of enzymes related to alcohol metabolism ( Han et al, 2021 ). As depicted in Fig.…”

Section: Resultsmentioning

confidence: 99%

Ganoderic acids-rich ethanol extract from Ganoderma lucidum protects against alcoholic liver injury and modulates intestinal microbiota in mice with excessive alcohol intake

Guo

Cao

You

et al. 2022

Current Research in Food Science

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Section: Resultsmentioning

confidence: 99%

Ganoderic acids-rich ethanol extract from Ganoderma lucidum protects against alcoholic liver injury and modulates intestinal microbiota in mice with excessive alcohol intake

Guo

Cao

You

et al. 2022

Current Research in Food Science

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“…Briefly, Lactobacillus , a therapeutically relevant bacterial genus, decreased after alcohol intake, which can be further restored through various bioactive compounds and natural products [ 70 , 74 , 78 , 79 , 96 , 97 ]. Lactobacillus is a beneficial bacteria that produces bacteriocins such as antibiotics, which further inhibit harmful microbes of the Enterobacteriaceae family, such as Salmonella or Shigella [ 107 ].…”

Section: Discussionmentioning

confidence: 99%

“…The results revealed that cornel iridoid glycoside supplementation significantly attenuated ALD via enhancing antioxidant activities, reducing inflammation, and altering intestinal microbial diversity. Cornel iridoid glycoside supplementation increased the abundance of Lactobacillus and decreased the proportion of norank_f_Muribaculaceae and norank_f_Desulfovibrionaceae in mice [ 70 ]. Furthermore, ursolic acid and antrodin A have recently been reported in two different studies to protect against alcohol-induced liver injury via the gut-liver axis [ 71 , 72 ].…”

Section: Protective Effect Of Natural Products and Their Bioactive Co...mentioning

confidence: 99%

The Beneficial Effects of Natural Extracts and Bioactive Compounds on the Gut-Liver Axis: A Promising Intervention for Alcoholic Liver Disease

et al. 2022

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Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. It can cause fatty liver (steatosis), steatohepatitis, fibrosis, cirrhosis, and liver cancer. Alcohol consumption can also disturb the composition of gut microbiota, increasing the composition of harmful microbes and decreasing beneficial ones. Restoring eubiosis or preventing dysbiosis after alcohol consumption is an important strategy in treating ALD. Plant natural products and polyphenolic compounds exert beneficial effects on several metabolic disorders associated with ALD. Natural products and related phytochemicals act through multiple pathways, such as modulating gut microbiota, improving redox stress, and anti-inflammation. In the present review article, we gather information on natural extract and bioactive compounds on the gut-liver axis for the possible treatment of ALD. Supplementation with natural extracts and bioactive compounds promoted the intestinal tight junction, protected against the alcohol-induced gut leakiness and inflammation, and reduced endotoxemia in alcohol-exposed animals. Taken together, natural extracts and bioactive compounds have strong potential against ALD; however, further clinical studies are still needed.

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“…As expected, several animal models of MAFLD and alcoholic fatty liver disease have revealed increases in AST and ALT levels ( Lívero et al, 2014 , 2016 ; Barbosa et al, 2020 ; Souza et al, 2020 ; Mendes et al, 2021 ). The therapeutic effects of medicinal plants in reversing this increase in markers of liver damage are well described in the literature, especially the beneficial effects of flavonoids, glycosides, and alkaloids ( Ling et al, 2020 ; Zhang et al, 2020 ; Han et al, 2021 ; Niu et al, 2021 ; Ore et al, 2021 ; Sahlan et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Croton urucurana Baill. Ameliorates Metabolic Associated Fatty Liver Disease in Rats

et al. 2022

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Background: Metabolic associated fatty liver disease (MAFLD) affects a quarter of the worldwide population, but no drug therapies have yet been developed. Croton urucurana Baill. (Euphorbiaceae) is a medicinal species, that is, widely distributed in Brazil. It is used in popular medicine to treat gastrointestinal, cardiovascular, and endocrine system diseases. However, its hepatoprotective and lipid-lowering effects have not yet been scientifically investigated.Aim of the study: The present study investigated the effects of an extract of C. urucurana in a rat model of MAFLD that was associated with multiple risk factors, including hypertension, smoking, and dyslipidemia.Material and Methods: The phytochemical composition of C. urucurana was evaluated by liquid chromatography-mass spectrometry. Spontaneously hypertensive rats received a 0.5% cholesterol-enriched diet and were exposed to cigarette smoke (9 cigarettes/day for 10 weeks). During the last 5 weeks, the animals were orally treated with vehicle (negative control [C-] group), C. urucurana extract (30, 100, and 300 mg/kg), or simvastatin + enalapril (two standard reference drugs that are commonly used to treat dyslipidemia and hypertension, respectively). One group of rats that were not exposed to these risk factors was also evaluated (basal group). Blood was collected for the analysis of cholesterol, triglyceride, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels. The liver and feces were collected for lipid quantification. The liver was also processed for antioxidant and histopathological analysis.Results: The main constituents of the C. urucurana extract were flavonoids, glycosides, and alkaloids. The model successfully induced MAFLD, reflected by increases in AST and ALT levels, and induced oxidative stress in the C- group. Treatment with the C. urucurana extract (300 mg/kg) and simvastatin + enalapril decreased plasma and hepatic lipid levels. In contrast to simvastatin + enalapril treatment, C. urucurana reduced AST and ALT levels. Massive lesions were observed in the liver in the C- group, which were reversed by treatment with the C. urucurana extract (300 mg/kg).Conclusion:C. urucurana extract exerted promising hepatoprotective and lipid-lowering effects in a preclinical rat model of MAFLD.

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An iridoid glycoside from Cornus officinalis balances intestinal microbiome disorder and alleviates alcohol-induced liver injury

Cited by 13 publications

References 47 publications

Ganoderic acids-rich ethanol extract from Ganoderma lucidum protects against alcoholic liver injury and modulates intestinal microbiota in mice with excessive alcohol intake

Ganoderic acids-rich ethanol extract from Ganoderma lucidum protects against alcoholic liver injury and modulates intestinal microbiota in mice with excessive alcohol intake

The Beneficial Effects of Natural Extracts and Bioactive Compounds on the Gut-Liver Axis: A Promising Intervention for Alcoholic Liver Disease

Croton urucurana Baill. Ameliorates Metabolic Associated Fatty Liver Disease in Rats

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