An Iron-Based Cytosolic Catalase and Superoxide Dismutase Mimic Complex

Abstract

The development of metallodrugs with antioxidant activities is of importance as a way to protect organisms exposed to stressful conditions. Although iron chemistry in the presence of H(2)O(2) is usually associated with pro-oxidant activity, mainly via the Fenton reaction, we found that the mononuclear compound [Fe(HPClNOL)Cl(2)]NO(3) (1; C(15)H(18)Cl(3)FeN(4)O(4), a = 8.7751(3) A, b = 9.0778(4) A, c = 24.3869(10) A, beta = 93.370(2) degrees , monoclinic, P2(1)/c, Z = 4), containing the tripodal ligand 1-[bis(pyridin-2-ylmethyl)amino]-3-chloropropan-2-ol, decomposes hydrogen peroxide and superoxide anion in vitro as well as shows in vivo protection because it prevents the harmful effects promoted by H(2)O(2) on Saccharomyces cerevisiae cells, decreasing the level of lipid peroxidation. This protective effect was observed for wild-type cells, as well as for mutant cells, which do not present the antioxidant metalloenzymes catalase (Ctt1) or copper/zinc superoxide dismutase (Sod1).

Copper(II) complexes of coumarin-derived Schiff base ligands: Pro- or antioxidant activity in MCF-7 cells?

“…The complexes had a much lower catalytic efficiency than native CuZn-SOD, which has an IC 50 value of 0.04 µM, 32 showed that all three complexes behaved as SOD and CAT mimics and the Fe(III) complex exhibited the highest protective effect, followed by Cu(II) and Mn(II). 33 In terms of the complexes acting as DNA nucleases, their ability to disproportionate H 2 O 2 to oxygen and water, would argue against these complexes being good nucleases. Reasonable catalase activity could only be recorded for complex 3 (Table 5), which was identified as the most cytotoxic compound.…”

Zinc Chloride Protects against Streptozotocin-Induced Diabetic Nephropathy in Rats

“…Diabetic nephropathy is a severe, chronic complication of diabetes mellitus, and it is the leading cause of end-stage renal failure in diabetic patients [9]. It results from the combined effects of various genetic and environmental factors.…”

Manganese Transport, Trafficking and Function in Invertebrates

“…52,54,55 Complexes of both iron and copper exhibit superoxide scavenging activity, however these metal ions also exhibit pro-oxidant activity. [56][57][58][59] In contrast, manganese ions react poorly with hydrogen peroxide and do not generate the highly toxic hydroxyl radical, providing a beneficial antioxidant activity without the prooxidant side effects of other redox active metals. 50,60 It appears that Mn-antioxidants can serve to enhance oxidative stress protection when enzymatic antioxidants are insufficient in various organisms.…”