An isocratic normal-phase high-performance liquid chromatographic method for the simultaneous determination of benzoyl peroxide and benzoic acid in one pharmaceutical preparation and their stability in different solvents

Hamdu, Hazim Hamid

doi:10.9790/3008-09110412

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…The process was carried out for a total of 12 min, feeding for 2 min at 30 rpm, then 10 min at 60 rpm. The processing time took into account that the BPO half-life at 130 °C is 1 min . The same method was followed for a PBAT-pulp biocomposite (P-PBAT), a reference of PBAT with deionized water in the same amount present in 15 vol % of never-dried pulp fibers (PBAT_H 2 O), and cross-linked PBAT in the presence of water (X-PBAT).…”

Section: Methodsmentioning

confidence: 99%

“…The processing time took into account that the BPO half-life at 130 °C is 1 min. 25 The same method was followed for a PBAT-pulp biocomposite (P-PBAT), a reference of PBAT with deionized water in the same amount present in 15 vol % of never- All of the materials were shaped into squared films of 1 mm thickness using a compression molder Buscher-Guyer KHL 100 at 130 °C for 3 min at 40 bar and 1 min at 500 bar, followed by quenching to room temperature under pressure. For demonstration of heat-shrinkage and for disintegration tests, the thickness was reduced to 0.1 mm.…”

Section: ■ Introductionmentioning

confidence: 99%

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Reusable, Recyclable, and Biodegradable Heat-Shrinkable Melt Cross-Linked Poly(butylene adipate-co-terephthalate)/Pulp Biocomposites for Polyvinyl Chloride Replacement

Avella,

Salse,

Sessini

et al. 2024

ACS Sustainable Chem. Eng.

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Heat-shrinkable films are widely used as disposable secondary packaging but are conventionally made from fossilbased and nonbiodegradable polyvinyl chloride or polyethylene. To lower the environmental impact of such products, this work reports the development of recyclable, biodegradable, and partially biosourced heat-shrinkable biocomposites that are costcompetitive with existing shrink wraps. Poly(butylene adipate-co-terephthalate), a growing biodegradable thermoplastic, was simultaneously reinforced with pulp fibers and partially cross-linked in a single-step reactive melt processing. The designed peroxideinitiated reaction led to a 55 wt % cocontinuous insoluble gel incorporating all the pulp fibers into a cross-linked polymer network. In the solid state, the cross-linked biocomposite shows 60% elongation at break with a 200% increase in Young's modulus, while the only addition of pulp fibers stiffens and embrittles the matrix. Creep tests in the melt state indicated that the cross-linked network induces homogeneous shrinking even during the loading phase, demonstrating the potential use of the biocomposites as heatshrinkable films. The shrinking also promotes the shape-memory of the biocomposite, which retains its dimensions after four cycles. The circularity of the materials was assessed by mechanical recycling and industrial composting, which have proven feasible end-oflife options for heat-shrinkable biocomposites.

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Section: Methodsmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Reusable, Recyclable, and Biodegradable Heat-Shrinkable Melt Cross-Linked Poly(butylene adipate-co-terephthalate)/Pulp Biocomposites for Polyvinyl Chloride Replacement

Avella,

Salse,

Sessini

et al. 2024

ACS Sustainable Chem. Eng.

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“…As tabulated in Table 2, poly (AN-co minute at 131˚C [37]. Thus, BPO took a longer time to dissociate at 60˚C and therefore, achieved more than 60% of yield but only at a reaction time of 96 hours.…”

Section: Yields Of the Polymerisation Of Poly (An-co-dvb-80)mentioning

confidence: 97%

The Synthesis and Characterisations of Porous Thioamide-Sulfonated-Modified Poly (Acrylonitrile-<em>Co</em>-Divinylbenzene-80) as a Potential Sorbent to Capture Polar Analytes

Ismail¹,

Jamil²,

Cormack³

et al. 2018

Preprint

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Pharmaceuticals contain biologically active components that can pollute water courses as a result of the excretions from individuals and/or uncontrolled release of residues from chemical plants, and they can pose a hazard to health. Pharmaceutical residues can persist at low concentrations in the environment, and thus may be potentially harmful to aquatic animals and to humans.  Controlling and monitoring such residues are therefore a prime interest, for example, a solid-phase extraction uses solid sorbents to purify and preconcentrate the residues prior to their chemical analysis. In the present study, poly (acrylonitrile-co-divinylbenzene-80) sorbents are synthesised by varying the comonomer feed ratios under precipitation polymerisation conditions to deliver a family of porous polymer microspheres. Acrylonitrile confers polar characters onto the sorbents, and the acrylonitrile-derived nitrile groups can be chemically transformed via polymer-analogous reactions into thioamide and sulfonated residues which make the sorbents even more suitable for the capture of polar analytes, including selected pharmaceuticals. The utility of the porous thioamide-sulfonated containing sorbents is demonstrated via the dispersion-solid phase extraction of mefenamic acid from aqueous media; mefenamic acid is an anthranilic acid derivative which is a potent, non-steroidal anti-inflammatory drug which is found in environmental waters at low concentrations.

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Benzoic acid and its derivatives as naturally occurring compounds in foods and as additives: Uses, exposure, and controversy

Olmo

Calzada

Núñez

2015

Critical Reviews in Food Science and Nutrition

275

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Benzoic acid is an aromatic carboxylic acid naturally present in plant and animal tissues, which can also be produced by microorganisms. Benzoic acid and a wide range of derivatives and related benzenic compounds, such as salts, alkyl esters, parabens, benzyl alcohol, benzaldehyde, and benzoyl peroxide, are commonly used as antibacterial and antifungal preservatives and as flavoring agents in food, cosmetic, hygiene, and pharmaceutical products. As a result of their widespread occurrence, production, and uses, these compounds are largely distributed in the environment and found in water, soil, and air. Consequently, human exposure to them can be high, common, and lengthy. This review is mainly focused on the presence and use of benzoic acid in foods but it also covers the occurrence, uses, human exposure, metabolism, toxicology, analytical methods for detection, and legal limits for benzoic acid and its derivatives. Their controversial effects and potential public health concerns are discussed.

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An isocratic normal-phase high-performance liquid chromatographic method for the simultaneous determination of benzoyl peroxide and benzoic acid in one pharmaceutical preparation and their stability in different solvents

Cited by 3 publications

References 11 publications

Reusable, Recyclable, and Biodegradable Heat-Shrinkable Melt Cross-Linked Poly(butylene adipate-co-terephthalate)/Pulp Biocomposites for Polyvinyl Chloride Replacement

Reusable, Recyclable, and Biodegradable Heat-Shrinkable Melt Cross-Linked Poly(butylene adipate-co-terephthalate)/Pulp Biocomposites for Polyvinyl Chloride Replacement

The Synthesis and Characterisations of Porous Thioamide-Sulfonated-Modified Poly (Acrylonitrile-<em>Co</em>-Divinylbenzene-80) as a Potential Sorbent to Capture Polar Analytes

Benzoic acid and its derivatives as naturally occurring compounds in foods and as additives: Uses, exposure, and controversy

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