An Isoprecipitin Distinguishing Polymorphism of Human Serum α&lt;sub&gt;1&lt;/sub&gt; Globulin

Kasukawa, Reiji; Yoshida, Takeo; Milgrom, Felix

doi:10.1159/000230756

Cited by 3 publications

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References 2 publications

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“…Allotypy of a2-macroglobulins has been reported in several animal species [8,12,14] and in man [4]. The human «-globulin allotype first described by Kasukawa et al [11] and recently shown to be present on «»-macroglobulin [13] is shared by several species. It re mains to be seen if this specificity is present on the same molecule in sheep serum as allotypes C, E or H. The fast a, mobility and apparently high sialic acid content of the component carrying allotype B may indi cate a molecular homology with seromucoid [22].…”

Section: Discussionmentioning

confidence: 99%

Studies on Allotypes in Sheep

Bash¹,

Milgrom²

1972

Int Arch Allergy Immunol

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An antiserum obtained from a sheep immunized with pooled sheep vitreous body was shown to contain allotypic antibodies which defined a specificity designated A. Subsequent immunization of 5 sheep with sheep sera elicited antibodies which recognized 7 additional allotypic specificities designated B, C, D, E, F, G and H. Comparison of antigenic specificities in double diffusion gel precipitation indicated that in sera containing allotypes C and E, C and H, or E and H, both allotypes were often expressed on the same molecule although subpopulations of molecules possessing only one of the specificities could also be demonstrated. Physicochemical tests characterized A and B as relatively small α-glycoproteins. Specificity A was apparently determined by carbohydrate while specificity B was manifested by the protein portion of a molecule rich in sialic acid. Specificities C, E and H appeared to be carried by α₂-macroglobulin. Allotypes A, B, D, F and G were shown to be synthesized in utero while specificities C, E and H were not detected in fetuses. Transplacental crossing of allo-type-bearing components was not demonstrated. Inheritance of allotypes appeared to be under control of dominant autosomal genes. Convincing evidence for Mendelian dominant inheritance was presented on the basis of family studies for allotypes A, B and E. The occurrence of allotype combinations in the general population along with results of specific matings suggested that the inheritance of C, E and H may be determined by gene complexes.

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Section: Discussionmentioning

confidence: 99%

Studies on Allotypes in Sheep

Bash¹,

Milgrom²

1972

Int Arch Allergy Immunol

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“…In studying the immune sera obtained from rabbits injected with macromolecular proteins from a pool of human sera containing allotypic antigen AL-M [1,2], one antigen different from AL-M was detected in the double diffusion gel precipitation reaction between the absorbed an tiserum and some but not all human sera. The antigen was found more frequently in the sera of pregnant women and of estrogen-treated male patients than in sera of other normal and sick human beings.…”

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An Inherited and Pregnancy-Associated α<sub>2</sub>-Globulin in Japanese Sera

Kasukawa¹,

Yoshida²,

Yoshida³

1973

Int Arch Allergy Immunol

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In trying to obtain rabbit immune sera to allotypic antigen AL-M, rabbit antisera were obtained which detected a pregnancy-associated antigen in human sera. In the Japanese population, the antigen was present in up to 100% of pregnancy sera, in 49% of adult female sera and in 9% of adult male and children sera. The antigen seemed to be controlled by an autosomal recessive gene, though its expression was strongly influenced by female hormones. The antigen was heat-labile macromolecule with electrophoretic mobility of a serum α₂-globulin. This antigen was quite similar to Pa 1 α₂-globulin reported by MacLaren et al. with respect to its frequency of inheritance and the physicochemical properties.

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α₂‐MACROGLOBULIN POLYMORPHISM: A NEW GENETIC SYSTEM DETECTED BY IMMUNOELECTROPHORESIS

Gallango

Castillo

1974

Int J Immunogenetics

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SUMMARY A rabbit anti‐human serum allowed the identification of a new human polymorphism of the α2‐macroglobulin. This polymorphism is represented by three variants: A, having a fast electrophoretic mobility; B, intermediate mobility; and C having a slower migration and the three combinations: AB, AC and BC. Preliminary genetic studies suggest that inheritance is of Mendelian autosomal co‐dominant type.

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An Isoprecipitin Distinguishing Polymorphism of Human Serum α<sub>1</sub> Globulin

Cited by 3 publications

References 2 publications

Studies on Allotypes in Sheep

Studies on Allotypes in Sheep

An Inherited and Pregnancy-Associated α<sub>2</sub>-Globulin in Japanese Sera

α₂‐MACROGLOBULIN POLYMORPHISM: A NEW GENETIC SYSTEM DETECTED BY IMMUNOELECTROPHORESIS

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An Isoprecipitin Distinguishing Polymorphism of Human Serum α<sub>1</sub> Globulin

Cited by 3 publications

References 2 publications

Studies on Allotypes in Sheep

Studies on Allotypes in Sheep

An Inherited and Pregnancy-Associated α<sub>2</sub>-Globulin in Japanese Sera

α2‐MACROGLOBULIN POLYMORPHISM: A NEW GENETIC SYSTEM DETECTED BY IMMUNOELECTROPHORESIS

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α₂‐MACROGLOBULIN POLYMORPHISM: A NEW GENETIC SYSTEM DETECTED BY IMMUNOELECTROPHORESIS