District heating and cooling networks can pose the possibility of including a variety of renewable energy sources as well as waste heat into a district’s heat supply concept. Unfortunately, low demand densities as they increasingly occur through higher building energy standards and in rural areas render conventional heating and cooling networks inefficient. At the same time, power-to-heat is becoming more and more important to make use of a larger amount of renewable energy sources on the electrical side by providing more flexibility by means of demand response and demand-side management. Within this work, a rural Plus-Energy settlement is presented addressing those topics by a low-temperature district heating and cooling network connected to a novel agrothermal collector supplying 23 residential buildings with decentralized heat pumps and PV systems. The collector, the network, and six of the buildings are equipped with comprehensive monitoring equipment. Within those buildings, forecast and optimization algorithms are implemented to adapt their heat pump operation to enable an increase of self-consumption, to include flexible electricity tariffs, and also to participate in power markets. Thereby, for the low-temperature district heating and cooling network, it has been shown that the concept can operate in the future at competitive heat costs. On the building level, up to 50% of cost savings could be achieved under ideal conditions with the optimization of the self-consumption of PV electricity. However, to ensure optimal results, the individual system components have to be dimensioned for this task.