Let X 1 , X 2 be two independent (two-sided) fractional Brownian motions having the same Hurst parameter H ∈ (0, 1), and let Y be a standard (one-sided) Brownian motion independent of (X 1 , X 2 ). In dimension 2, fractional Brownian motion in Brownian motion time (of index H) is, by definition, the processYt ), t 0. The main result of the present paper is an Itô's type formula for f (Z t ), when f : R 2 → R is smooth and H ∈ [1/6, 1). When H > 1/6, the change-ofvariable formula we obtain is similar to that of the classical calculus. In the critical case H = 1/6, our change-of-variable formula is in law and involves the third partial derivatives of f as well as an extra Brownian motion independent of (X 1 , X 2 , Y ). We also discuss the case H < 1/6.