An LC-MS profiling method reveals a route for apocarotene glycosylation and shows its induction by high light stress in Arabidopsis

Mi, Jianing; Jia, Kun-Peng; Balakrishna, Aparna; Wang, Jian You; Al‐Babili, Salim

doi:10.1039/c8an02143k

Cited by 20 publications

(21 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of β‐CC can induce the xenobiotic detoxification pathway (D'Alessandro et al ., ), but the question arises as to whether it is also a substrate for these detoxifying chemical modifications. A possible answer to this question can be inferred from the recent demonstration that apocarotenoid hydroxylation and glycosylation are enhanced under high light conditions (Mi et al ., ). In this context, it is interesting to note that 1 O 2 as well as β‐CC have a strong up‐regulating effect on the expression of several glycosyl transferases in Arabidopsis leaves (Ramel et al ., , ).…”

Section: Homeostasis Of β‐Ccmentioning

confidence: 97%

“…Although the measured levels of GAPO7 are just a fraction of the β‐CC concentration (1.67%), while most of the β‐ionone is present as GAPO9 (575%), this process suggests that β‐carotene derivatives are targeted by detoxifying mechanisms. Furthermore, unlike hydroxylated β‐ionone, hydroxy‐β‐cyclocitral was not detectable, suggesting a fast conversion to the glycosylated form and therefore the importance of this process in β‐CC homeostasis and in the regulation of β‐CC signaling (Mi et al ., ). The β‐CC metabolization described above limits its signaling role and may constitute a negative feedback mechanism to return 1 O 2 signaling back to unstressed levels.…”

Section: Homeostasis Of β‐Ccmentioning

confidence: 97%

See 1 more Smart Citation

Sensing β‐carotene oxidation in photosystem II to master plant stress tolerance

D’Alessandro

Havaux

2019

New Phytologist

View full text Add to dashboard Cite

Stressful environmental conditions lead to the production of reactive oxygen species in the chloroplasts, due to limited photosynthesis and enhanced excitation pressure on the photosystems. Among these reactive species, singlet oxygen ( 1 O 2 ), which is generated at the level of the PSII reaction center, is very reactive, readily oxidizing macromolecules in its immediate surroundings, and it has been identified as the principal cause of photooxidative damage in plant leaves. The two b-carotene molecules present in the PSII reaction center are prime targets of 1 O 2 oxidation, leading to the formation of various oxidized derivatives. Plants have evolved sensing mechanisms for those PSII-generated metabolites, which regulate gene expression, putting in place defense mechanisms and alleviating the effects of PSII-damaging conditions. A new picture is thus emerging which places PSII as a sensor and transducer in plant stress resilience through its capacity to generate signaling metabolites under excess light energy. This review summarizes new advances in the characterization of the apocarotenoids involved in the PSIImediated stress response and of the pathways elicited by these molecules, among which is the xenobiotic detoxification.

show abstract

Section: Homeostasis Of β‐Ccmentioning

confidence: 97%

Section: Homeostasis Of β‐Ccmentioning

confidence: 97%

Sensing β‐carotene oxidation in photosystem II to master plant stress tolerance

D’Alessandro

Havaux

2019

New Phytologist

View full text Add to dashboard Cite

show abstract

“…The transcriptome reprograming process, triggered by β-cyclocitral, increases the plant tolerance to photo-oxidative stress and initiates acclimation to high light conditions (Ramel et al, 2012b). Recently, it was shown that high light leads to a significant increase in the content of glycosylated β-cyclocitral (Mi et al, 2019b), which might be a mechanism for deactivation of this signaling molecule (D’Alessandro and Havaux, 2019).…”

Section: Novel Carotenoid-derived Signaling Moleculesmentioning

confidence: 99%

Apocarotenoids Involved in Plant Development and Stress Response

et al. 2019

Self Cite

View full text Add to dashboard Cite

Carotenoids are isoprenoid pigments synthesized by all photosynthetic organisms and many heterotrophic microorganisms. They are equipped with a conjugated double-bond system that builds the basis for their role in harvesting light energy and in protecting the cell from photo-oxidation. In addition, the carotenoids polyene makes them susceptible to oxidative cleavage, yielding carbonyl products called apocarotenoids. This oxidation can be catalyzed by carotenoid cleavage dioxygenases or triggered nonenzymatically by reactive oxygen species. The group of plant apocarotenoids includes important phytohormones, such as abscisic acid and strigolactones, and signaling molecules, such as β-cyclocitral. Abscisic acid is a key regulator of plant's response to abiotic stress and is involved in different developmental processes, such as seed dormancy. Strigolactone is a main regulator of plant architecture and an important signaling molecule in the plant-rhizosphere communication. β-Cyclocitral, a volatile derived from β-carotene oxidation, mediates the response of cells to singlet oxygen stress. Besides these wellknown examples, recent research unraveled novel apocarotenoid growth regulators and suggests the presence of yet unidentified ones. In this review, we describe the biosynthesis and biological functions of established regulatory apocarotenoids and touch on the recently identified anchorene and zaxinone, with emphasis on their role in plant growth, development, and stress response.

show abstract

“…The diapocarotenoid anchorene (C 10 ) is found in several plant species (e.g., tomato, carrot, spinach). Although it seems possible that the cleavage of C11–C12 and C11′–C12′ double bonds from carotenoids downstream of ζ‐carotene results in the production of anchorene, it is still unclear how it is formed (Jia et al ., 2019; Mi et al ., 2019). Anchorene was shown to promote the development of ANR (Figure 7b, left panel) (Jia et al ., 2019).…”

Section: Cyclic and Acyclic Apocarotenoids With Signaling Propertiesmentioning

confidence: 99%

Plant apocarotenoids: from retrograde signaling to interspecific communication

et al. 2021

Self Cite

View full text Add to dashboard Cite

Summary Carotenoids are isoprenoid compounds synthesized by all photosynthetic and some non‐photosynthetic organisms. They are essential for photosynthesis and contribute to many other aspects of a plant's life. The oxidative breakdown of carotenoids gives rise to the formation of a diverse family of essential metabolites called apocarotenoids. This metabolic process either takes place spontaneously through reactive oxygen species or is catalyzed by enzymes generally belonging to the CAROTENOID CLEAVAGE DIOXYGENASE family. Apocarotenoids include the phytohormones abscisic acid and strigolactones (SLs), signaling molecules and growth regulators. Abscisic acid and SLs are vital in regulating plant growth, development and stress response. SLs are also an essential component in plants’ rhizospheric communication with symbionts and parasites. Other apocarotenoid small molecules, such as blumenols, mycorradicins, zaxinone, anchorene, β‐cyclocitral, β‐cyclogeranic acid, β‐ionone and loliolide, are involved in plant growth and development, and/or contribute to different processes, including arbuscular mycorrhiza symbiosis, abiotic stress response, plant–plant and plant–herbivore interactions and plastid retrograde signaling. There are also indications for the presence of structurally unidentified linear cis‐carotene‐derived apocarotenoids, which are presumed to modulate plastid biogenesis and leaf morphology, among other developmental processes. Here, we provide an overview on the biology of old, recently discovered and supposed plant apocarotenoid signaling molecules, describing their biosynthesis, developmental and physiological functions, and role as a messenger in plant communication.

show abstract

An LC-MS profiling method reveals a route for apocarotene glycosylation and shows its induction by high light stress in Arabidopsis

Abstract: Apocarotenoid glycosylation serves as a valve regulating carotenoid homeostasis in plants and may contribute to their response to photo-oxidative stress.

Cited by 20 publications

References 53 publications

Sensing β‐carotene oxidation in photosystem II to master plant stress tolerance

Sensing β‐carotene oxidation in photosystem II to master plant stress tolerance

Apocarotenoids Involved in Plant Development and Stress Response

Plant apocarotenoids: from retrograde signaling to interspecific communication

Contact Info

Product

Resources

About