High-rise buildings with an active mass damper/driver (AMD) system generally use a simplified mathematical model. e result leads to parametric uncertainties including the stiffness and mass variations exist, and the accuracy of its controller is seriously affected. In view of the above uncertainties, based on a Lyapunov stability theory and linear matrix inequality (LMI) approach, a state feedback controller based on the guaranteed cost control (GCC) algorithm is proposed in this paper. A ten-storey frame with an AMD system is taken as a numerical example, and its control effect and AMD parameters are viewed as the control indexes. e performance of the proposed robust controller is compared with a conventional controller based on the classical LQR algorithm. e analysis results show that the new controller effectively suppresses the dynamic responses of high-rise buildings with parametric uncertainties and keeps the AMD parameters stable. Finally, a four-storey steel experimental frame with an AMD system is used to verify the correctness of the conclusions.