A circuit for calibrating the output response of sensors is proposed in this paper. It is based on the Progressive Polynomial Method and is intended to be integrated, whenever possible, with the sensor itself in the same chip. The proposed circuit was designed for a specific sensor, a MIM-ISFET, which was modeled in HSpice. The calibration circuit reduces the error in the output signal due to process variations of both the sensor and the interface circuit from 13% to 2% in the whole sensing range. The circuit was designed in a 0.18µm standard CMOS process and consumes 2.3mW .