2024
DOI: 10.1101/2024.05.10.593534
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An MST-based assay reveals new binding preferences of IFIT1 for canonically and non-canonically capped RNAs

Tomasz Spiewla,
Katarzyna Grab,
Anais Depaix
et al.

Abstract: IFIT proteins (interferon-induced proteins with tetratricopeptide repeats) are key components of the innate immune response that bind to viral and cellular RNA targets to inhibit viral translation and replication. The RNA target recognition is guided by molecular patterns, particularly at the RNA 5' ends. IFIT1 preferably binds RNAs modified with the 7-methylguanosine (m7G) cap-0 structure, while RNAs with cap-1 structure are recognized with lower affinity. Less is known about the propensity of IFIT1 to recogn… Show more

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