An NBD-armed tetraaza macrocyclic lysosomal-targeted fluorescent probe for imaging copper(ii) ions

Abstract

An NBD-armed tetraaza macrocyclic lysosomal-targeted fluorescent probe for detecting Cu(2+) was synthesized and used for fluorescence imaging in HeLa cells. The probe was specifically localized in lysosomes and successfully applied to visualize Cu(2+) as well as to monitor Cu(2+) level changes in the lysosomes of living cells.

Stabilisation of Exotic Tribromide (Br3−) Anions via Supramolecular Interaction with a Tosylated Macrocyclic Pyridinophane. A Serendipitous Case

“…It was later in the spotlight for its ability to form metal complexes [6][7][8], but its wider success was achieved thanks to its utilisation as a scaffold for the preparation of new materials that have proven effective in a variety of applications. Indeed, L derivatives decorated with different hanging functionalities have been studied for several biomedical (MRI contrast agents [9][10][11][12], antiproliferative treatments [13][14][15][16], radiotherapy [17,18], enzyme mimicking [19,20] and antioxidant activity [21][22][23]), chemosensing [24][25][26][27] and catalytic [28][29][30][31][32][33] applications. Very recently, (MRI contrast agents [9][10][11][12], antiproliferative treatments [13][14][15][16], radiotherapy [17,18], enzyme mimicking [19,20] and antioxidant activity [21][22][23]), chemosensing [24][25]…”

“…Anion-π interactions were also found to play an important role in the formation of highly organised polyiodide complexes [44,45] and iodide based permutable organised frameworks (POF) [46] with a pyridinium-based ligand such as Stoddart's blue box (BB, cyclobis(paraquat-p-phenylene)). (MRI contrast agents [9][10][11][12], antiproliferative treatments [13][14][15][16], radiotherapy [17,18], enzyme mimicking [19,20] and antioxidant activity [21][22][23]), chemosensing [24][25][26][27] and catalytic [28][29][30][31][32][33] applications. Very recently, it has been shown that L and its N-trimethylated derivative are capable of stabilising iodine-dense three-dimensional networks that might be relevant for crystal engineering purposes and the design of solid-state conductors [34].…”

“…It was later in the spotlight for its ability to form metal complexes [ 6 , 7 , 8 ], but its wider success was achieved thanks to its utilisation as a scaffold for the preparation of new materials that have proven effective in a variety of applications. Indeed, L derivatives decorated with different hanging functionalities have been studied for several biomedical (MRI contrast agents [ 9 , 10 , 11 , 12 ], antiproliferative treatments [ 13 , 14 , 15 , 16 ], radiotherapy [ 17 , 18 ], enzyme mimicking [ 19 , 20 ] and antioxidant activity [ 21 , 22 , 23 ]), chemosensing [ 24 , 25 , 26 , 27 ] and catalytic [ 28 , 29 , 30 , 31 , 32 , 33 ] applications. Very recently, it has been shown that L and its N-trimethylated derivative are capable of stabilising iodine-dense three-dimensional networks that might be relevant for crystal engineering purposes and the design of solid-state conductors [ 34 ].…”

Selective heavy metal removal and water purification by microfluidically-generated chitosan microspheres: Characteristics, modeling and application

“…The highly toxic nature and long persistence of these metals, such as lead (Pb), cobalt (Co), copper (Cu) and manganese (Mn), can cause serious health effects to flora and fauna. Excessive intake or long term exposure (accumulation effect) to toxic heavy metals will contribute to unexpected and irreversible physical health issues to humans, such as nervous system disorders, acute poisoning, as well as multi-organ failure [3][4][5][6].…”

Chemical characteristics of the products of the complexation reaction between copper(II) and a tetra-aza macrocycle in the presence of chloride ions

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Historically, transition metal tetra-aza complexes have been utilized extensively in biomimetic inorganic chemistry as functional models for superoxide dismutase, catalase, and copper oxidase active sites. [18][19][20][21][22][23][24][25] Metal complexes derived from tetra-aza macrocyclic ligands generally present large stability constants, on the order of log K ≥ 20.0 in the case of copper(II) complexes.…”