An NIF-doped ZIF-8 hybrid membrane for continuous antimicrobial treatment

Luo, Dan; Wang, Cuijuan; Yan, Tong; Liu, Cheng; Xiao, Yumei; Zhu, Zixin; Liu, Dongning; Wang, Yao‐Yu

doi:10.1039/d0ra00108b

Cited by 31 publications

(8 citation statements)

References 47 publications

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“…The activities of hydrogels were tested against the gram-negative bacterium E. coli and the gram-positive bacterium S. aureus showing good antibacterial activities 247 . The niflumic acid and 2-methylimidazole were incorporated to the sodium alginate composite material as a ligand for Zn(II) which had strong antibacterial property and processed sustained release behavior of Zn(II) and high drug loading effect 248 . Furthermore, the mixture of CD-MOFs and polyacrylic acid (PAA) were fabricated by a solid in oil-in-oil (s/o/o) emulsifying solvent evaporation method, which presented a favorable dispersion of drug loaded CD-MOF nanocrystals (IBU and lansoprazole) mixed with PAA matrices and the uniform distribution of the drug molecules within these crystals.…”

Section: Applications Of Mofs In Therapy and Drug Deliverymentioning

confidence: 99%

Metal-organic frameworks for advanced drug delivery

et al. 2021

Acta Pharmaceutica Sinica B

292

116

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Metal-organic frameworks (MOFs), comprised of organic ligands and metal ions/metal clusters via coordinative bonds are highly porous, crystalline materials. Their tunable porosity, chemical composition, size and shape, and easy surface functionalization make this large family more and more popular for drug delivery. There is a growing interest over the last decades in the design of engineered MOFs with controlled sizes for a variety of biomedical applications. This article presents an overall review and perspectives of MOFs-based drug delivery systems (DDSs), starting with the MOFs classification adapted for DDSs based on the types of constituting metals and ligands. Then, the synthesis and characterization of MOFs for DDSs are developed, followed by the drug loading strategies, applications, biopharmaceutics and quality control. Importantly, a variety of representative applications of MOFs are detailed from a point of view of applications in pharmaceutics, diseases therapy and advanced DDSs. In particular, the biopharmaceutics and quality control of MOFs-based DDSs are summarized with critical issues to be addressed. Finally, challenges in MOFs development for DDSs are discussed, such as biostability, biosafety, biopharmaceutics and nomenclature.

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Section: Applications Of Mofs In Therapy and Drug Deliverymentioning

confidence: 99%

Metal-organic frameworks for advanced drug delivery

et al. 2021

Acta Pharmaceutica Sinica B

292

116

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“…It can be seen from the size of the inhibitory area that the composite membrane has a good antibacterial effect on E. coli in Table 2 28 . It can be seen compared with the antibiotic a alone (a) the composite membrane (c) has a larger inhibitory area in Figure 5, indicating that the antibacterial effect on E. coli is better, because ZIF‐NIF has a unique structure that can improve the dispersion of metal ions and antibiotics in three dimensions, so the compound can be loaded more drugs.…”

Section: Resultsmentioning

confidence: 99%

“…In the previous work, the structure of ZIF-niflumic acid (NIF)-alginate (ALG) was reported, the membrane showed high drug loading, responsive drug release, excellent antibacterial properties, and biocompatibility. 28 After preliminary research on the antibacterial properties of the membrane, in order to gain a deeper understanding of the impact of the membrane on the energy metabolism of bacteria and the impact of these metabolic changes on the survival rate of bacteria, this paper expands the system research on the physical properties of the membrane and its antibacterial mechanism. Observe the changes of bacterial energy metabolism through the detection of respiratory metabolic enzyme activity.…”

Section: Introductionmentioning

confidence: 99%

“…Zn(II) as a bactericidal factor, 24–27 when contacted with the cell membrane of bacteria, because the cell membrane is negatively charged, the two are coulomb attracted, thereby firmly binding, allowing metal ions to penetrate the cell membrane, reacting with proteins after entering the bacteria, destroying the synthesis of enzymes, thereby disturbing The synthesis of its DNA leads to bacterial death. In the previous work, the structure of ZIF–niflumic acid (NIF)–alginate (ALG) was reported, the membrane showed high drug loading, responsive drug release, excellent antibacterial properties, and biocompatibility 28 . After preliminary research on the antibacterial properties of the membrane, in order to gain a deeper understanding of the impact of the membrane on the energy metabolism of bacteria and the impact of these metabolic changes on the survival rate of bacteria, this paper expands the system research on the physical properties of the membrane and its antibacterial mechanism.…”

Section: Introductionmentioning

confidence: 99%

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The Antibacterial Mechanism of Zn(II) Frame Supported on Alginate Membrane

Luo

Wang

et al. 2020

Bulletin Korean Chem Soc

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In order to solve the problem of antibiotic-resistant bacteria caused by excessive use of antibiotics, herein, an antibacterial membrane composed of natural sodium alginate (ALG), zeolite imidazolate skeleton (ZIF-8) and niflumic acid (NIF) was reported. The membrane serves as a versatile platform for local antibacterial. This report carried out in-depth research on the physical properties and antibacterial mechanism of the synthesized sodium alginate composite film. The data shows that the sodium alginate-based antibacterial film has a continuous antibacterial effect, and the release of antibacterial molecules can be controlled according to changes in the external environment. The results show that the complex has stronger mechanical and bacteriostatic properties. Niflumic acid and Zn(II) have synergistic antibacterial effect. The complex promotes bacterial death by hindering bacterial respiratory metabolism and destroying cell membrane structure.

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“…The sterilization mechanisms include (1) the production of ROS stimulated by light, (2) zinc ions released out of ZIF-8 framework as a toxin to inhibit bacterial growth, and (3) the fact that nanocomposites with a rough surface could greatly influence the interactions between bacterial cells and thus play a bactericidal role. Besides, MOFs also had the ability to combine with other materials, such as activated carbon (Azad et al, 2016), polyvinylidene fluoride/perfluorooctyltriethoxysilane (Miao et al, 2018), sodium alginate/niflumic acid (Luo et al, 2020), and humic acid (Liu et al, 2020), to form hybrids to improve their antibacterial performance. All of them have greatly expanded the application potential and efficiency of MOF materials as antimicrobial agents.…”

Section: The Modified Nanomaterials Possessing Excellent Antibacteriamentioning

confidence: 99%

Microporous Frameworks as Promising Platforms for Antibacterial Strategies Against Oral Diseases

Wan

Ren

et al. 2020

Front. Bioeng. Biotechnol.

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Nowadays, the heavy burden of oral diseases such as dental caries, periodontitis, endodontic infections, etc., and their consequences on the patients' quality of life indicate a strong need for developing effective therapies. Bacterial infections played an important role in the field of oral diseases, in-depth insight of such oral diseases have given rise to the demand for antibacterial therapeutic strategies. Recently, microporous frameworks have attracted tremendous interest in antibacterial application due to their well-defined porous structures for drug delivery. In addition, intensive efforts have been made to enhance the antibacterial performance of microporous frameworks, such as ion doping, photosensitizer incorporation as building blocks, and surface modifications. This review article aims on the major recent developments of microporous frameworks for antibacterial applications against oral diseases. The first part of this paper puts concentration on the cutting-edge researches on the versatile antibacterial strategies of microporous materials via drug delivery, inherent activity, and structural modification. The second part discusses the antibacterial applications of microporous frameworks against oral diseases. The applications of microporous frameworks not only have promising therapeutic potential to inhibit bacterial plaque-initiated oral infectious diseases, but also have a wide applicability to other biomedical applications.

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An NIF-doped ZIF-8 hybrid membrane for continuous antimicrobial treatment

Abstract: A ZIF-8 hybrid film has shows continuous medical effects, with including antibacterial and anti-inflammatory effects.

Cited by 31 publications

References 47 publications

Metal-organic frameworks for advanced drug delivery

Metal-organic frameworks for advanced drug delivery

The Antibacterial Mechanism of Zn(II) Frame Supported on Alginate Membrane

Microporous Frameworks as Promising Platforms for Antibacterial Strategies Against Oral Diseases

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