An NIR-triggered and thermally responsive drug delivery platform through DNA/copper sulfide gates

Zhang, Lei; Li, Yecheng; Jin, Zexun; Yu, Jimmy C.; Chan, King Ming

doi:10.1039/c5nr02767e

Cited by 51 publications

(35 citation statements)

References 62 publications

(103 reference statements)

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“…1 Among the various external stimuli, the high spatial and temporal resolution of near-infrared (NIR) light, has shown to be highly beneficial for drug delivery. [2][3][4][5] NIR-triggerable drug delivery platforms are largely based on NIR absorbing nanomaterials, notably on reduced graphene oxide (rGO) based matrixes. [6][7][8][9] The effectiveness of rGO as NIRabsorbing photothermal agent compared to other carbon allotropes is due to the rapid light-toheat conversion of rGO under low-power NIR irradiation.…”

Section: Introductionmentioning

confidence: 99%

Near-infrared light activatable hydrogels for metformin delivery

Pagneux

Voronova

et al. 2019

Nanoscale

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Drug loaded hydrogels have proven to be versatile controlled-release systems. We report here on heat active hydrogels' formation by mixing graphene oxide (GO) or carboxyl enriched reduced graphene oxide (rGO-COOH) with metformin hydrochloride, an insulin sensitizer drug currently used as first line therapy to treat patients with type 2 diabetes. The driving forces of the gelation process between the graphene-based nanomaterial and metformin are hydrogen bonding and electrostatic interactions, weakened at elevated temperature. Using the excellent photothermal properties of the graphene matrixes, we demonstrate that these supramolecular drug reservoirs can be photothermally activated for transdermal metformin delivery. A sustained delivery of metformin was achieved using a laser power of 1 W cm -2 . In vitro assessment of the key target Glucose-6 Phosphatase (G6P) gene expression using Human hepatocyte model confirmed that metformin activity was unaffected by photothermal activation.In vivo, metformin was detected in mice plasma at 1h post-activation of the metformin loaded rGO-COOH gel.

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Section: Introductionmentioning

confidence: 99%

Near-infrared light activatable hydrogels for metformin delivery

Pagneux

Voronova

et al. 2019

Nanoscale

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“…Overexpressed or specifically expressed receptors in various cancer tissues and cells are reported in literature [65][66][67][68][69][70]. NIRtriggered organic-inorganic hybrid silica drug carriers include mainly two components; NIR absorption agents and a drugcontaining silica (mostly mesoporous) moiety, which can enable a synergistic treatment for cancer cells via dual effects of photothermal ablation and chemotherapy [72]. As for stimuli responsive systems, especially Near-Infrared (NIR) triggered multifunctional organic-inorganic hybrid silica nanoparticles are commonly used as cancer theranostics.…”

Section: Organic-inorganic Hybrid Silicas With Target-ligand Interactmentioning

confidence: 99%

“…As for stimuli responsive systems, especially Near-Infrared (NIR) triggered multifunctional organic-inorganic hybrid silica nanoparticles are commonly used as cancer theranostics. NIRtriggered organic-inorganic hybrid silica drug carriers include mainly two components; NIR absorption agents and a drugcontaining silica (mostly mesoporous) moiety, which can enable a synergistic treatment for cancer cells via dual effects of photothermal ablation and chemotherapy [72]. Photothermal therapy (PTT) employs near-infrared (NIR) laser photo-absorbers to generate heat upon NIR laser irradiation.…”

Section: Theranostic Approachmentioning

confidence: 99%

Silica‐based organic‐inorganic hybrid nanoparticles and nanoconjugates for improved anticancer drug delivery

Ilhan‐Ayisigi

Yeşil-Çeliktaş

2018

Engineering in Life Sciences

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After the introduction of first generation MSNs for drug delivery with some challenges such as large particle sizes, irregular morphologies and aggregations, second generation provided uniform spherical morphologies, tunable pore/particle sizes and compositions. Henceforth, organic‐inorganic hybrid mesoporous silica nanosystems have grown rapidly and utilized for active and passive targeting of tumorigenic cells especially conjugated with organic polymers followed by third generation counterparts with improved functionalities for cancer therapy. The aim of this review article is to focus on the advancements in mesoporous silica based organic‐inorganic hybrid nanoparticles developed as drug carriers targeting cancer cells. Brief introduction to the state‐of‐the‐art in passive and active targeting methods is presented. Specifically, therapeutic, diagnostic and theranostic applications are discussed with emphases on triggered and ligand conjugated organic‐inorganic hybrid mesoporous silica nanomaterials. Although mesoporous silica nanoparticles perform well in preclinical tests, clinical translation progresses slowly as appropriate doses needs to be evaluated for human use along with biocompatibility and efficiency depending on surface modifications.

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“…This can be called autonomous release of anticancer drugs (Table 1). Second, MSNs that respond to external stimuli such as light [41–52], and magnetic field [53–59] have been developed. Use of ultrasound to trigger drug release has also been explored [60].…”

Section: Mesoporous Silica Nanoparticle (Msn)-based Controlled Relmentioning

confidence: 99%

“…One example is the use of copper sulfide nanoparticles attached to MSN by two complementary oligonucleotides which act as a cap (gate) to prevent release of Doxorubicin (DOX) from MSN [52]. NIR irradiation causes temperature increase resulting in the release of DOX [52]. Another example is the use of NIR-light-absorbing plasmonic nanomaterials.…”

Section: Mesoporous Silica Nanoparticle (Msn)-based Controlled Relmentioning

confidence: 99%

Development of mesoporous silica-based nanoparticles with controlled release capability for cancer therapy

Mekaru

Lü

Tamanoi

2015

Advanced Drug Delivery Reviews

240

145

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Nanoparticles that respond to internal and external stimuli to carry out controlled release of anticancer drugs have been developed. In this review, we focus on the development of mesoporous silica based nanoparticles, as this type of materials provides a relatively stable material that is amenable to various chemical modifications. We first provide an overview of various designs employed to construct MSN-based controlled release systems. These systems respond to internal stimuli such as pH, redox state and the presence of biomolecules as well as to external stimuli such as light and magnetic field. They are at a different stage of development; depending on the system, their operation has been demonstrated in aqueous solution, in cancer cells or in animal models. Efforts to develop MSNs with multi-functionality will be discussed. Safety and biodegradation of MSNs, issues that need to be overcome for clinical development of MSNs, will be discussed. Advances in the synthesis of mechanized theranostic nanoparticles open up the possibility to start envisioning future needs for medical equipment.

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An NIR-triggered and thermally responsive drug delivery platform through DNA/copper sulfide gates

Cited by 51 publications

References 62 publications

Near-infrared light activatable hydrogels for metformin delivery

Near-infrared light activatable hydrogels for metformin delivery

Silica‐based organic‐inorganic hybrid nanoparticles and nanoconjugates for improved anticancer drug delivery

Development of mesoporous silica-based nanoparticles with controlled release capability for cancer therapy

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