An O18 Study of the Hemoglobin Degradation to Biliverdin in the Model Reaction*

Fk, Anan; Hs, Mason

doi:10.1093/oxfordjournals.jbchem.a127369

Cited by 11 publications

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“…A stoicheiometric relationship has been demonstrated between the amount of CO exhaled and the amount of haemoglobin broken down per day by human subjects. The formation in vitro of bile pigment and CO in stoicheiometric proportions has been demonstrated from myoglobin (Sj6strand, 1952), haemoglobin (Anan & Mason, 1961) and protoferrihaem (haemin) (Ludwig et al, 1957). Brown & Jones (1968) studied the kinetics of the oxidation of protoferrihaem to bile pigment by H202 by using a conventional spectrophotometric method.…”

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confidence: 99%

Oxidation of deuteroferrihaem by hydrogen peroxide

Jones

Prudhoe

Robson

1973

Biochemical Journal

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1. The oxidation of deuteroferrihaem by H(2)O(2) to bile pigment and CO was studied both by stopped-flow kinetic spectrophotometry and mass spectrometry, at 25 degrees C, I=0.1m. 2. Spectrophotometric studies imply that, at constant pH, the rate of bile pigment formation is first-order with respect to [H(2)O(2)] and also proportional to [deuteroferrihaem monomer]. The effect of pH on the apparent second-order rate constant suggests that acid-ionization of deuteroferrihaem monomer is important in the reaction mechanism. 3. The relative rates of formation of O(2) (from catalytic decomposition of H(2)O(2)) and CO (from oxidation of ferrihaem) have been measured by mass spectrometry. The results are in excellent agreement with those obtained by combining kinetic data for catalytic decomposition (Jones et al., 1973, preceding paper) with the spectrophotometric results for deuteroferrihaem oxidation.

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confidence: 99%

Oxidation of deuteroferrihaem by hydrogen peroxide

Jones

Prudhoe

Robson

1973

Biochemical Journal

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“…( 5) They concluded from analyses of the bile pigment that two or more atoms of molecular oxygen might have been incorporated during the oxidation and suggested a mechanism of biliverdin formation involving hydroxyl radicals. ( 5) They concluded from analyses of the bile pigment that two or more atoms of molecular oxygen might have been incorporated during the oxidation and suggested a mechanism of biliverdin formation involving hydroxyl radicals.…”

Section: Fig 20 Summary Hypothetical Scheme For the Formation Of Bimentioning

confidence: 99%