An observation of histological evidence on internal organ damages in mice caused by repeated exposures to motorcycle emissions

Wardoyo, Arinto Yudi Ponco; Juswono, Unggul P.; Noor, Johan A. E.

doi:10.1063/1.4983418

Cited by 5 publications

(5 citation statements)

References 32 publications

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“…In each field, the number of normal and abnormal tubular epithelial cells were counted, while the level of Bowman’s space was measured ( Fig. 2 ) [ 18 ]. Normal tubular epithelial cells had no edema and vacuolation [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

Varied dose exposures to ultrafine particles in the motorcycle smoke cause kidney cell damages in male mice

2018

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Section: Methodsmentioning

confidence: 99%

Varied dose exposures to ultrafine particles in the motorcycle smoke cause kidney cell damages in male mice

2018

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“…The changes in the mice liver include the central vein, hepatocyte cell form, and sinusoid blood vessel (Fig. 7) [9]. The centralist vein shape that is originally a spherical shape and unbroken.…”

Section: Liver Damagementioning

confidence: 99%

“…Pollutants can pass through the body through respiration and oral processes. The presence of pollutants in the body will be able to disrupt the function of organs, including the kidney as the main organ in the excretory system [6,7], the lungs as respiratory organs [8], the liver that plays an important role in the process of detoxification, and blood as the most fluid in the body [9,10].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Transfluthrin as the Active Substance of One Push Aerosol Repellent on Organs Damage of Mice (Mus Musculus) (Case Study of Lung, Liver, Bloods, and Kidney)

Juswono¹

2019

GEOMATE

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One push aerosol repellent used by the public contains an active substance called transfluthrin. Transfluthrin is mostly pyrethroid synthetic which has functions as neurotoxin substance. It may act as free radicals in the body due to the compounds which have one free electron that makes it reactive. The purpose of this study was to investigate the effects of transfluthrin on mice organs. In this study, the experimental animals (Wistar mice) were put in an exposure chamber and exposed by one push aerosol repellent contains around 20-25% of transfluthrin one time a day for 15 days. The damage of mice organs was identified by the microscopic picture (400x of magnification). The results showed that the expose of repellent contains about 20-25% of transfluthrin on mice increase the damage of lung, liver, blood, and kidney cells from 13% to 24%, 12% to 27%, 9% to 69% and 22% to 55%, respectively.

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“…This study has established that it is very important to determine particles size (pad particles) to investigate the risk of deposition into the respiratory tract during inhalation, causing particles connected with posing hazards to oxidative stress and inflammation (10). Other researchers have shown that ultrafine particles may become bloodborne and translocate to other tissues such as the liver, kidneys, and brain (11).…”

Section: Introductionmentioning

confidence: 99%

Histological Changes in the Lung and Liver of Mice Treated with Brake Pad Particles

Ghaidan¹

2019

Baghdad Sci.J

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In the present study, the effects of brake pad particles of lung and liver histological sections were evaluated for (60) adult male mice. The animals were divided into three groups ( A,B,C) according to the periods of exposure (4, 8, and 12) weeks respectively exposed to brake pad particles in addition to the control groups (F) exposed to fresh air only. A special inhalation chamber designed locally has been used to expose the animals. The exposure to brake pad particles was (2.228) µg/m³ for 30 min/day, 5 days/week for (4,8and12) weeks respectively. The examination in group (A) of the histological sections of the lung showed the thickness of interalveolar septa. Also, a congestion of alveolar capillary was marked indicating pulmonary emphysema. The infiltration of alveolar macrophages showed the engulfed foreign particles (pad particles) within their cytoplasm, and peribronchial fibrosis. Group (B) showed the presence of pad particles (anthracosis), whereas the bronchial tree showed bronchitis with the bronchus-hyperplasia of mucin-producing cells (epithelial hyperplasia). Still another section showed an infiltration of mononuclear leukocytes and focal lobar necrosis. The third group (C), in turn, revealed acute interstitial bronchopneumonia with peribronchial focal necrosis and mild pulmonary edema with alveolar anthracosis. As regards the liver, group (A) showed mild central venous congestion. Group (B), on the other hand, gave acute hepatitis, congestion of the central vein hyaline degeneration and mitotic figure having 2-3 nuclei. Severe congestion of the central vein with vascular amyloid deposition and most of the hepatocytes revealed coagulate necrosis in group (C). These changing tissues increased with increasing the exposure periods and were clearer in group (C) which was exposed for 12 weeks. The continuous exposure to brake pad particles lead to damaging important body organs tissues and effect on human health, these particles can be considered as a type of pollutants added to air pollutants in different cities of Iraq.

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An observation of histological evidence on internal organ damages in mice caused by repeated exposures to motorcycle emissions

Cited by 5 publications

References 32 publications

Varied dose exposures to ultrafine particles in the motorcycle smoke cause kidney cell damages in male mice

Varied dose exposures to ultrafine particles in the motorcycle smoke cause kidney cell damages in male mice

The Effects of Transfluthrin as the Active Substance of One Push Aerosol Repellent on Organs Damage of Mice (Mus Musculus) (Case Study of Lung, Liver, Bloods, and Kidney)

Histological Changes in the Lung and Liver of Mice Treated with Brake Pad Particles

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