An Observation of Thromboxane A₂ in Arterial Blood after Cholesterol Feeding in Rabbits

Abstract

Agents responsible for the entry of cholesterol-bearing lipoproteins into the arterial wall represent local risk factors in atherogenesis. In an attempt to identify these agents, we inserted a catheter into the ascending aorta of rabbits and 5ml of arterial blood sample was withdrawn.

Biology and therapeutic potential of prostacyclin.

“…Platelets from patients with arterial thrombosis, deep venous thrombosis, or recurrent venous thrombosis produce more PG endoperoxides and TXA 2 than normal and have a shortened survival time. 50 Platelets from rabbits made atherosclerotic by dietary manipulation 51 and from patients who have survived myocardial infarction 52 are abnormally sensitive to aggregating agents and produce more TXA 2 than controls. Elevated TXB 2 levels have been demonstrated in the blood of patients with Prinzmetal's angina 53 and vasotonic angina.…”

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“…Platelets from patients with arterial thrombosis, deep venous thrombosis, or recurrent venous thrombosis produce more prostaglandin endoperoxides and TXA2 than normal and have a shortened survival time (Lagarde & Dechavanne, 1977). Platelets from rabbits made atherosclerotic by dietary manipulation (Shimamoto, Kobayashi, Takahashi, Takashima, Sakamoto & Morooka, 1978) and from patients who have survived myocardial infarction (Szczeklik, Gryglewski, Musial, Grodzinska, Serwonska & Marcinkiewicz, 1978b) are abnormally sensitive to aggregating agents and produce more TXA2 than controls. Elevated TXB2 levels have been demonstrated in the blood of patients with Prinzmetal's angina (Lewy, Smith, Silver, Saia, Walinsky & Wiener, 1979) and vasotonic angina (Robertson, Robertson, Roberts, Maas, FitzGerald, Friesinger & Oates, 1981).…”

Prostacyclin: its biosynthesis, actions and clinical potential

“…Increased production of prostaglandin endoperoxides or TXB2 vitro by platelets has been found in blood from patients with arterial thrombosis, deep venous thrombosis or recurrent thrombosis; these conditions are associated with a shortened platelet survival time (Lagarde & Dechavanne 1977). In addition, increased sensitivity of platelets to aggregating agents and increased release of TXB2 has been described in rabbits made atherosclerotic by diet (Shimamoto et al 1978) and in patients who survived myocardial infarction (Szczeklik et al 1978 a). An increased level of TXB2 in blood has been observed in patients with Prinzmetal's angina (Lewy et al 1979).…”