2022
DOI: 10.1093/trstmh/trac006
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An observational assessment of the safety of mass drug administration for trachoma in Ethiopian children

Abstract: Background The International Trachoma Initiative (ITI) provides azithromycin for mass drug administration (MDA) to eliminate trachoma as a public health problem. Azithromycin is given as tablets for adults and powder for oral suspension (POS) is recommended for children aged <7 y, children <120 cm in height (regardless of age) or anyone who reports difficulty in swallowing tablets. An observational assessment of MDA for trachoma was conducted to determine the frequency with whic… Show more

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Cited by 3 publications
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“…Some of our respondents described initial concerns about taking up to nine pills at one time. NTD programshave gone to great lengths in recent years to reduce the chance of choking PLOS NEGLECTED TROPICAL DISEASES [14]. Recent studies and policy documents have discussed a variety of possible causes of previous choking episodes, including pressure for compliance from the health work force, social pressure amongst beneficiaries, a lack of patient awareness and a lack of perceived right of refusal [14,15].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Some of our respondents described initial concerns about taking up to nine pills at one time. NTD programshave gone to great lengths in recent years to reduce the chance of choking PLOS NEGLECTED TROPICAL DISEASES [14]. Recent studies and policy documents have discussed a variety of possible causes of previous choking episodes, including pressure for compliance from the health work force, social pressure amongst beneficiaries, a lack of patient awareness and a lack of perceived right of refusal [14,15].…”
Section: Discussionmentioning
confidence: 99%
“…NTD programshave gone to great lengths in recent years to reduce the chance of choking PLOS NEGLECTED TROPICAL DISEASES [14]. Recent studies and policy documents have discussed a variety of possible causes of previous choking episodes, including pressure for compliance from the health work force, social pressure amongst beneficiaries, a lack of patient awareness and a lack of perceived right of refusal [14,15]. We created specific diagrams for the health work force to use during co-administration, encouraging a 'two pills, swallow, pause, two pills.…”
Section: Discussionmentioning
confidence: 99%
“…The availability of azithromycin as an oral suspension for trachoma elimination and the new rapidly disintegrating, chewable formulation of mebendazole and orally dispersible formulation of praziquantel represent significant advances for MDA safety. Recent data from Ethiopia suggest that risk of choking and other adverse swallowing events is significantly lower among young children who are given azithromycin oral suspension than for children receiving albendazole tablets (whether crushed or not) for STH [ 15 , 65 ]. Therefore, coadministering whole deworming tablets with azithromycin oral suspension may represent a significant increase in choking risk compared to oral suspension alone.…”
Section: Discussionmentioning
confidence: 99%