2014
DOI: 10.4038/cmj.v59i4.7865
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An observational study of alopecia areata in Sri Lankan adult patients

Abstract: Objectives The objectives were to assess the demographical pattern, clinical presentation and therapeutic response in a cohort of patients with alopecia areata (AA) in Sri Lanka.Methods Hospital-based observational study of 290 adults aged 18 years or above.

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Cited by 26 publications
(40 citation statements)
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“…e406 / Arch Argent Pediatr 2017;115(6):e404-e411 / Review studies: 1) family-based linkage, 2) studies in monozygotic twins, in which a concordance of 50% of developing the disease has been observed, 14 and 3) studies based on heritability in first-degree relatives, 10 in which a positive family incidence of 10 to 42% for AA has been reported. 16 Three percent of patients have at least one brother with the disease and 2% have at least one affected child, 10 with an estimated risk of 6%, in children of patients with AA.…”
Section: Genetic Factorsmentioning
confidence: 99%
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“…e406 / Arch Argent Pediatr 2017;115(6):e404-e411 / Review studies: 1) family-based linkage, 2) studies in monozygotic twins, in which a concordance of 50% of developing the disease has been observed, 14 and 3) studies based on heritability in first-degree relatives, 10 in which a positive family incidence of 10 to 42% for AA has been reported. 16 Three percent of patients have at least one brother with the disease and 2% have at least one affected child, 10 with an estimated risk of 6%, in children of patients with AA.…”
Section: Genetic Factorsmentioning
confidence: 99%
“…However, British and Japanese treatment guidelines for AA have suggested topical immunotherapy (dinitrochlorobenzene, diphenylcyclopropenone o el squaric acid dibutylester) as one of the most effective options, 7,8 although intralesional, topical or systemic corticosteroids (fluocinolone acetonide, triamcinolone acetonide, dexamethasone, clobetasol propionate and methylprednisolone), are used in patients with AA. 10,14 Other treatment options include anthralin, azathioprine, 10 cyclosporine, methotrexate, sulfasalazine, minoxidil, 21 adalimumab, 29 tofacitinib and ruxolitinib. 57,58 All of which are oriented towards eliminating inflammation, preventing hair loss, and controlling symptoms.…”
Section: Treatmentmentioning
confidence: 99%
“…12 La AA no distingue géneros, aunque algunos trabajos sugieren que tiene una ligera predominancia por las mujeres. 3,13 Sin embargo, esto puede depender de la población estudiada, dado que, en países como la India y Turquía, el mayor número de casos corresponde al sexo masculino, 14 que presenta las formas más graves en comparación con las mujeres (63% vs. 36%, respetivamente). 15 Además, se ha reportado que la AA podría afectar a todos los grupos de edad, 16 aunque alrededor del 25% de los individuos son niños.…”
Section: Epidemiologíaunclassified
“…Se estima que la probabilidad de que un paciente con AA lo presente es de 2 veces mayor que la población general, aunque los pacientes con AT y AU tienen un riesgo más alto, mientras que las personas que ya tienen vitiligo tienen 4 veces más posibilidad de desarrollar AA. 26 Además, se ha observado que 2,3% de los pacientes con enfermedad tiroidea, 3,2% de los pacientes con diabetes mellitus tipo 1, 0,9% con artritis reumatoide, 10-60% con anemia perniciosa y 4,1% de pacientes con vitiligo podrían desarrollar AA, 14,27 aunque la enfermedad de Addison, lupus eritematoso sistémico, miastenia gravis, esclerodermia, rinitis alérgica, dermatitis atópica, asma 24 y psoriasis 28 también han sido asociadas, por lo tanto, una historia positiva de enfermedades autoinmunes podría representar un grupo importante de pacientes con AA. 10 Aunado a esto, se ha hipotetizado que la AA es causada porque los pacientes desarrollan anticuerpos que actúan contra la estructura de sus propios folículos pilosos en la fase anágena y, en relación con ello, se ha observado que los …”
Section: Factores Inmunológicosunclassified
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