An Observational Study of the Occurrence of Serious Adverse Reactions among Patients Who Receive Optison in Routine Medical Practice

Wei, Kevin; Shah, Sangeeta; Jaber, Wael A.; DeMaria, Anthony N.

doi:10.1016/j.echo.2014.04.020

Cited by 10 publications

(3 citation statements)

References 18 publications

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“…No further treatment is necessary, pain should resolve spontaneously within a few minutes. In case of further need of UCA in these patients, an alternative such as SonoVue or Optison may be used [48].…”

Section: Adverse Eventsmentioning

confidence: 99%

Contrast echocardiography: a practical guideline from the British Society of Echocardiography

Hampson,

Senior,

Ring

et al. 2023

Echo Res Pract

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Ultrasound contrast agents (UCAs) have a well-established role in clinical cardiology. Contrast echocardiography has evolved into a routine technique through the establishment of contrast protocols, an excellent safety profile, and clinical guidelines which highlight the incremental prognostic utility of contrast enhanced echocardiography. This document aims to provide practical guidance on the safe and effective use of contrast; reviews the role of individual staff groups; and training requirements to facilitate its routine use in the echocardiography laboratory.

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Section: Adverse Eventsmentioning

confidence: 99%

Contrast echocardiography: a practical guideline from the British Society of Echocardiography

Hampson,

Senior,

Ring

et al. 2023

Echo Res Pract

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“…Optison ® under US application has been used for temporary disruption of the BBB, though side effects like vasoconstriction and hemorrhages might occur with sub-optimal US setting ( Hynynen et al, 2001 ; Raymond et al, 2007 ). For echocardiography, application of Optison ® was found to be generally safe in patients with different cardiologic problems, and potential induction of myocardial necrosis was ruled out ( Borges et al, 2002 ; Wei et al, 2014 ). Nonetheless, in patients with an unstable cardiopulmonary status or an acute myocardial infarction, application is contraindicated ( Dolan et al, 2009 ).…”

Section: Diagnosticsmentioning

confidence: 99%

“…Adverse effects though are rare and generally mild and temporary, and unlike other imaging modalities, USCA have been safely applied to patients with renal diseases, kidney failure or a generally very bad health condition without an increase in side effects. In at least three cases, however, patients died after SonoVue ® injection, but it is uncertain if the CA injections caused the events ( van der Wouw et al, 2000 ; ter Haar, 2009 ; Wei et al, 2014 ).…”

Section: Biodistribution and Degradationmentioning

confidence: 99%

Evolution of contrast agents for ultrasound imaging and ultrasound-mediated drug delivery

2015

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Ultrasound (US) is one of the most frequently used diagnostic methods. It is a non-invasive, comparably inexpensive imaging method with a broad spectrum of applications, which can be increased even more by using bubbles as contrast agents (CAs). There are various different types of bubbles: filled with different gases, composed of soft- or hard-shell materials, and ranging in size from nano- to micrometers. These intravascular CAs enable functional analyses, e.g., to acquire organ perfusion in real-time. Molecular analyses are achieved by coupling specific ligands to the bubbles’ shell, which bind to marker molecules in the area of interest. Bubbles can also be loaded with or attached to drugs, peptides or genes and can be destroyed by US pulses to locally release the entrapped agent. Recent studies show that US CAs are also valuable tools in hyperthermia-induced ablation therapy of tumors, or can increase cellular uptake of locally released drugs by enhancing membrane permeability. This review summarizes important steps in the development of US CAs and introduces the current clinical applications of contrast-enhanced US. Additionally, an overview of the recent developments in US probe design for functional and molecular diagnosis as well as for drug delivery is given.

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Contrast Echocardiography: Latest Developments and Clinical Utility

Porter

Xie

2015

Curr Cardiol Rep

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Ultrasound enhancing agents (UEAs) are being utilized for a growing number of applications with real-time very low mechanical index (MI) techniques in clinical cardiology today. This article will review recent developments on the safety of UEAs and their effectiveness in myocardial perfusion imaging, three-dimensional quantification of left ventricular function, and vascular imaging. UEAs are now being utilized in all age groups, with new indications that add incremental value to the currently approved by the Food and Drug Administration. These include the incremental value in cardiac imaging, where the off-label analysis of myocardial perfusion observed with UEAs adds to the enhanced endocardial border delineation. In carotid artery imaging, UEAs improve the detection of plaque but also can examine plaque neovascularization. Vascular surgeons now utilize UEAs in the evaluation of endovascular repair to detect endoleaks without the need of ionizing radiation. Newer applications are emerging in the detection of left atrial appendage thrombi and quantification of myocardial blood flow and volume in transplant patients.

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An Observational Study of the Occurrence of Serious Adverse Reactions among Patients Who Receive Optison in Routine Medical Practice

Cited by 10 publications

References 18 publications

Contrast echocardiography: a practical guideline from the British Society of Echocardiography

Contrast echocardiography: a practical guideline from the British Society of Echocardiography

Evolution of contrast agents for ultrasound imaging and ultrasound-mediated drug delivery

Contrast Echocardiography: Latest Developments and Clinical Utility

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