2023
DOI: 10.21203/rs.3.rs-2545922/v1
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An Observational Study of the Pharmacokinetics of Adductor Canal Block using Liposomal Bupivacaine and Standard Bupivacaine in Total Knee Arthroplasty

Abstract: Background Periarticular local infiltration of analgesia (LIA) and regional nerve block using adductor canal block (ACB) have been effective in managing postoperative pain for total knee arthroplasty (TKA). It has been shown that combining ACB with LIA can significantly reduce pain scores and morphine consumption compared with LIA alone. However, this raises concerns about the potential risk of local anesthetic systemic toxicity (LAST), especially with the large doses of total local anesthetic used in both LIA… Show more

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