An observational study of the association between androgenetic alopecia and size of the prostate

Abstract

Introduction:Androgenetic alopecia (AGA) is characterized by miniaturization of the hair follicle, leading to vellus transformation of the terminal hair follicle. It is caused by interactions between androgens, several genes, and environmental factors with hair follicles. Benign prostatic hyperplasia (BPH) is highly prevalent among elderly men but infrequent in those younger than 40 years. Because both entities share a common pathogenesis and AGA manifests before the onset of BPH, there could be an association between AGA and BPH.Aim:To study the possible association between AGA and the size of prostate.Materials and Methods:Sixty-five consecutive male patients, 35–65 years of age with AGA of Hamilton–Norwood classification Grades 3–7, were included in the study. AGA of Grades 1 and 2 patients on treatment with minoxidil, finasteride, or other treatments for AGA with history of prostate cancer or prostate disease were excluded from the study. Prostate size was measured through transabdominal ultrasonography. Statistical analysis was done with SPSS software.Results:Of the 65 AGA patients, the mean age was 47.18 years. Grade 4 AGA was the most common grade seen in 19 patients (29.2%), out of which, most (47.4%) were in the 56–65 years age group. 52.3% patients had normal prostate volume, and 47.7% had an enlarged prostate. The percentage of patients with the normal and enlarged prostate in moderate Grade 3 AGA was 68.8% and 31.2%, and in severe Grade 6 AGA, it was 33.3% and 66.7%, respectively. Prostate enlargement was more likely to occur in severe AGA than in moderate AGA(odds ratio 3.311; P = 0.025, which is significant).Conclusion:This study revealed an increase in prostate size with increasing age, with higher prevalence of Grade 1 prostate enlargement in younger individuals, and with higher prevalence of Grade 3 prostate enlargement in elderly men. The study also found a positive correlation between AGA and prostate size, with higher grades of AGA having higher prostate volume.

From causes of aging to death from COVID-19

“…Cosmetic manifestations such as aging spots and wrinkles, while not deadly by themselves, can be manifestations of other diseases. For example, baldness correlates with prostate enlargement [ 60 ], and the later can lead to urinary obstruction and renal failure.…”

Hemorrhagic Cystitis in Allogeneic Stem Cell Transplantation: A Role for Age and Prostatic Hyperplasia

“…Prostatic volume and diameters were assessed in males by an expert urologist by revising radiological pre-HSCT imaging when available. Prostatic hyperplasia was radiologically considered of grade 0 when up to 20 cc, then it was graded as follows: grade 1 20-40 cm^3, grade 2 40-60 cm^3, grade 3 60-80 cm^3, grade 4 for more than 80 cm^3 in volume 14 .…”

Non-surgical treatments for androgenetic alopecia: a literature review

“…[2] Występowanie AGA jest czynnikiem zwiększonego ryzyka chorób sercowo-naczyniowych, zaburzeń metabolizmu glukozy, cukrzycy typu 2 i powiększenia prostaty. [3,4,5,6,7] AGA jest dolegliwością uwarunkowaną czynnikami genetycznymi i hormonalnymi, związaną z nadmiernym pobudzeniem receptora androgenowego (AR) w komórkach mieszka włosowego. [8] Endogenne androgeny obejmują testosteron i dihydrotestosteron.…”