An observational study on adverse reactions of cosmetics: The need of practice the Cosmetovigilance system

Lucca, Jisha M; Joseph, Royes; Kubaish, Zainab Hussain Al; Al-Maskeen, Sarah Mohammad; Alokaili, Zainab Ali

doi:10.1016/j.jsps.2020.04.017

Cited by 30 publications

(42 citation statements)

References 23 publications

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“…"Cosmetovigilance is a model of safety monitoring of cosmetics. It can be considered as one of the elements in public health activities" [32]. This public health policy is a legal way of gathering information on the safety of cosmetics and their ingredients, in order to reduce the risks associated with cosmetics use [12,31].…”

Section: Discussionmentioning

confidence: 99%

Global Trends in Cosmetics Use-Related Adverse Effects: A Bibliometric Analysis of Literature Published during 1957–2021

et al. 2021

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Cosmetic and beauty products, though not essential for physical health, go a long way in providing mental well-being and confidence, and hence are used substantially. Increasing utilization of varying cosmetic products leads to a multitude of adverse effects. There is more awareness about cosmeceutics, cosmetic products and their adverse effects, and studies on the same are currently trending. Bibliometrics has become a prominent and growing field of research in recent years. The aim of this research was to assess bibliometric features and conduct systematic trend analysis on the literature available on cosmetics’ adverse effects. We analyzed all the published documents that included the keywords “cosmetics” and “adverse effects” between 1957 and 2021. We performed a detailed scientometric and bibliometric assessment in this field. A total of 4127 articles were retrieved from the databases provided by Scopus, which most were original articles. The United States ranked first and dominated the literature with 1292 (31.44%) documents followed by South Korea 7.47%. Harvard medical school was the most productive institution (1.16%). The study of the adverse effects of cosmetics should be supported and taken up by the researchers/authors from developing and underdeveloped countries.

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Section: Discussionmentioning

confidence: 99%

Global Trends in Cosmetics Use-Related Adverse Effects: A Bibliometric Analysis of Literature Published during 1957–2021

et al. 2021

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“…Furthermore, 34.7% of the population in the United States reported the experience of different health problems upon exposure to fragranced products [3]. In all these studies, perfumes were reported as one of the fragranced products that contributed to the reported health reactions [3][4][5]. The lower rate in our study can be justified by the fact that we targeted perfume products exclusively, while other studies included all types of fragranced products during their assessment.…”

Section: Discussionmentioning

confidence: 98%

“…A study conducted recently among 425 adults in the Eastern Province of Saudi Arabia reported that 50.6% of the participants had an adverse reaction from a fragranced product, including perfumes [5]. Internationally, a study conducted across four countries, including the United States, the United Kingdom, Australia, and Sweden showed that 32.2% of the participants reported sensitivity from fragranced products, including perfumes [4].…”

Section: Discussionmentioning

confidence: 99%

“…A total rate of 32.2% of the public reported sensitivity to fragranced products, including perfumes, in a study that included four different countries [4]. In Saudi Arabia, 50.6% of the participants of a study reported at least one adverse reaction from cosmetic products, including perfumes [5]. Fragrance substances added to cosmetic products and perfumes contributed to the majority of health adverse reactions caused by fragranced products [1,2].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and Risk Factors of Self-Reported Perfume Sensitivity in Saudi Arabia

et al. 2021

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Perfumes are widely used products; however, several fragrance substances used in perfuming are well-established allergenic substances and have been attributed to various adverse health reactions. The nature and significance of perfume sensitivity reactions have not been thoroughly investigated. Therefore, this study aimed to identify the prevalence, nature, and associated risk factors of self-reported perfume sensitivity among the general population in Saudi Arabia. A nationally representative cross-sectional study was conducted among adults in Saudi Arabia in October 2020. Significant associated risk factors were explored using multivariate regression analyses. A total of 1078 participants completed the survey, with a mean age of 36.7 years (SD ± 10.36). Perfume sensitivity reactions were reported in 14.6% of participants. From among these participants, 17.8% reported moderate to severe reactions. Respiratory and skin symptoms were the most reported reactions, with total rates of 40.1% and 35.7%, respectively. History of asthma (OR = 3.2, 95%CI 1.88–4.37, p < 0.001) and the use of counterfeit perfume products (OR = 1.9, 95%CI 1.23–2.94, p < 0.003) were significantly associated with a higher risk of perfume sensitivity. Our study revealed that a considerable number of the general population in Saudi Arabia has experienced adverse health reactions due to perfume products. The enormous volume of the perfume market thus necessitates further quantitative analysis studies to determine the presence of allergenic fragrance substances in perfumes.

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“…The topical application of hesperidin improved skin barrier permeability [61]. What is important is that the compound has no toxic effects after neither oral nor topical application, whereas many ingredients present in cosmetic products may cause allergic reactions and be responsible for adverse systemic effects [52,[62][63][64][65]. Until now, animal models or tissue cultures have been used in studies of hesperidin, while the transdermal distribution of this polyphenol after application on human skin has never been analysed.…”

Section: Introductionmentioning

confidence: 99%

Mangiferin and Hesperidin Transdermal Distribution and Permeability through the Skin from Solutions and Honeybush Extracts (Cyclopia sp.)—A Comparison Ex Vivo Study

et al. 2021

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Polyphenolic compounds—mangiferin and hesperidin—are, among others, the most important secondary metabolites of African shrub Cyclopia sp. (honeybush). The aim of this study was to compare the percutaneous absorption of mangiferin and hesperidin from solutions (water, ethanol 50%, (v/v)) and extracts obtained from green and fermented honeybush (water, ethanol 50%, (v/v)). Research was performed with the Bronaugh cells, on human dorsal skin. The mangiferin and hesperidin distributions in skin layers (stratum corneum, epidermis, and dermis) and in acceptor fluid (in every 2, 4, 6, and 24 h) were evaluated by HPLC–Photodiode Array Coulometric and Coulometric Electrochemical Array Detection. The transdermal distribution of hesperidin was also demonstrated by fluorescence microscopy. Results indicated that mangiferin and hesperidin were able to cross the stratum corneum and penetrate into the epidermis and dermis. An advantage of hesperidin penetration into the skin from the water over ethanol solution was observed (451.02 ± 14.50 vs. 357.39 ± 4.51 ng/cm2), as well as in the mangiferin study (127.56 ± 9.49 vs. 97.23 ± 2.92 ng/cm2). Furthermore, mangiferin penetration was more evident from nonfermented honeybush ethanol extract (189.85 ± 4.11 ng/cm2) than from solutions. The permeation of mangiferin and hesperidin through the skin to the acceptor fluid was observed regardless of whether the solution or the honeybush extract was applied. The highest ability to permeate the skin was demonstrated for the water solution of hesperidin (250.92 ± 16.01 ng/cm2), while the hesperidin occurring in the extracts permeated in a very low capacity. Mangiferin from nonfermented honeybush ethanol extract had the highest ability to permeate to the acceptor fluid within 24 h (152.36 ± 8.57 ng/cm2).

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An observational study on adverse reactions of cosmetics: The need of practice the Cosmetovigilance system

Cited by 30 publications

References 23 publications

Global Trends in Cosmetics Use-Related Adverse Effects: A Bibliometric Analysis of Literature Published during 1957–2021

Global Trends in Cosmetics Use-Related Adverse Effects: A Bibliometric Analysis of Literature Published during 1957–2021

Prevalence and Risk Factors of Self-Reported Perfume Sensitivity in Saudi Arabia

Mangiferin and Hesperidin Transdermal Distribution and Permeability through the Skin from Solutions and Honeybush Extracts (Cyclopia sp.)—A Comparison Ex Vivo Study

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