As urbanisation intensifies, an increased proportion of human activities is observed to be conducted indoors, amplifying the imperative of a superior indoor living environment. Among the various facets influencing indoor environmental quality, thermal comfort emerges as a pivotal factor influencing both physical and mental well-being. While predominant research methodologies predominantly employ empirical evaluations, the nuanced impacts of interior architectural structures on airflow and temperature distribution often remain unaddressed. Furthermore, rigorous simulations based on fluid dynamics are frequently absent from these assessments. In this study, the interplay of heat transfer and ventilation within interior architecture is meticulously examined. A novel research framework is introduced, encapsulating evaluations of human thermal comfort in ventilated interiors, intricate indoor airflow simulations predicated on fluid dynamics, and the pioneering design strategies for optimised hollow and ventilated architectural interior wall systems.