2024
DOI: 10.3390/antibiotics13010055
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An Ocean between the Waves: Trends in Antimicrobial Consumption in Hospitalized Patients with COVID-19

Xavier Durà-Miralles,
Gabriela Abelenda-Alonso,
Alba Bergas
et al.

Abstract: We assessed the antibiotic use in SARS-CoV-2-infected patients during four different waves of the COVID-19 pandemic, as well as its trends over the period and associated risk factors. We performed a cross-sectional retrospective analysis nested in a prospectively collected cohort of hospitalized adult patients with COVID-19 at a university hospital in Spain. A total of 2415 patients were included in this study, among whom 1120 corresponded to the first wave. The highest percentage of patients receiving some so… Show more

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“…During the first waves of the COVID-19 pandemic, the consumption of penicillin with β-lactamase and carbapenems significantly increased in ICUs [16]. The main antibiotics prescribed in hospitalized patients with COVID-19 were amoxicillin/clavulanic acid, piperacillin/tazobactam, cephalosporines, and carbapenems [17]. The inappropriate use of antibiotic treatments was frequently described and could lead to infections by MDR bacteria, which have a significant impact on the management of hospitalized patients with COVID-19 infections, leading to a prolonged hospitalization time and increased mortality [7,8,15,18].…”
Section: Introductionmentioning
confidence: 99%
“…During the first waves of the COVID-19 pandemic, the consumption of penicillin with β-lactamase and carbapenems significantly increased in ICUs [16]. The main antibiotics prescribed in hospitalized patients with COVID-19 were amoxicillin/clavulanic acid, piperacillin/tazobactam, cephalosporines, and carbapenems [17]. The inappropriate use of antibiotic treatments was frequently described and could lead to infections by MDR bacteria, which have a significant impact on the management of hospitalized patients with COVID-19 infections, leading to a prolonged hospitalization time and increased mortality [7,8,15,18].…”
Section: Introductionmentioning
confidence: 99%