An ocular insert with zero-order extended delivery: Release kinetics and mathematical models

Mariz, M.; Murta, Joaquim; Gil, M.H.; Ferreira, Paula

doi:10.1016/j.ejpb.2022.10.023

Cited by 11 publications

(3 citation statements)

References 21 publications

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“…The simplified kinetic equation is derived from the mathematical model mentioned above The value of k in the Ritger–Peppas equation is discussed . When k ≤ 0.45, the drug release mechanism is Fick diffusion (Fickian Diffusion).…”

Section: Resultsmentioning

confidence: 99%

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Effect of Specific Surface Area and Hydrophobicity of Electrospun Nanofibers on the Sustained Release Performance of Diclofenac Sodium

Lao,

Wang,

et al. 2024

Langmuir

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Nanofibers produced by electrospinning are suitable options for slow-release materials. Diclofenac sodium (DS) is a nonsteroidal anti-inflammatory medication with a brief half-life that can serve as an effective sustained-release agent. This paper presents a novel method for producing DS-sustained release nanofibers by electrostatic spinning processes. During the preparation, the slow-release capabilities of biodegradable materials poly(lactic acid) (PLA) and polycaprolactone (PCL) are investigated. A composite drug-carrying scaffold is prepared to enhance the sustained-release performance. The sustained release ability is affected by the specific surface area of the nanofibers and the hydrophobicity of the polymer. The findings indicate that the composite nanofiber with a PLA/PCL ratio of 1:1 demonstrates the most effective sustained-release performance. The release rate is mostly influenced by the hydrophobicity of the polymer at this point. Sustained-release kinetic simulations were performed and revealed that the release of nanofibers follows a first-order release paradigm. This work presents a straightforward approach for creating a sustained-release formulation of DS.

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Section: Resultsmentioning

confidence: 99%

“…(first order model) The value of k in the Ritger−Peppas equation is discussed. 69 When k ≤ 0.45, the drug release mechanism is Fick diffusion (Fickian Diffusion). When 0.45 < k < 0.89, the drug release mechanism is non-Fick diffusion (anomalous transport), that is, the joint action of drug diffusion and skeleton dissolution.…”

Section: Mmentioning

confidence: 99%

Effect of Specific Surface Area and Hydrophobicity of Electrospun Nanofibers on the Sustained Release Performance of Diclofenac Sodium

Lao,

Wang,

et al. 2024

Langmuir

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“…The glass with tube thermostat at constant temperature of 37 °±1 °C. Sampling is carried out at equal intervals with filling of the receptor environment and analyze with spectrophotometric methods [52,54,55].…”

Section: Oi Standardizationmentioning

confidence: 99%

Ocular Inserets as a Modern Therapy Trend in Opthalmopathology

TURAEVA,

BAKHRUSHINA,

ZHALYALOVA

et al. 2023

Int J App Pharm

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Ocular insert (OI) has its wide recognition and importance from the 19th century around the world, the use of this dosage form in clinical practice was distributed throughout the USSR. The key issue covered in this review is the development of the ocular insert and their testing by specific parameters of quality. It is important to choose the right excipients and standardize ocular inserts according to pharmacopoeia articles (thickness, pH, biodegradation time). It is also important to control those indicators that increase patient compliance. Technology of solid dosage form consists of several stages: mixing, drying and cutting with packaging in primary polymer packaging. So the manufacturer does not need highly specialized equipment and staff skills. Based on this information, we can concluded that ocular inserts are promising and actively researched dosage form, which in the future, could fully complement or replace the medical drugs traditionally used in ophthalmology.

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