2010
DOI: 10.1371/journal.pone.0012225
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An Oligopeptide Transporter of Mycobacterium tuberculosis Regulates Cytokine Release and Apoptosis of Infected Macrophages

Abstract: BackgroundThe Mycobacterium tuberculosis genome encodes two peptide transporters encoded by Rv3665c-Rv3662c and Rv1280c-Rv1283c. Both belong to the family of ABC transporters containing two nucleotide-binding subunits, two integral membrane proteins and one substrate-binding polypeptide. However, little is known about their functions in M. tuberculosis. Here we report functional characterization of the Rv1280c-Rv1283c-encoded transporter and its substrate-binding polypeptide OppAMTB.Methodology/Principal Findi… Show more

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Cited by 51 publications
(41 citation statements)
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“…67 The importance of peptide transporters in the pathogenesis of M. tuberculosis also gets emphasized by the finding that ABC peptide transporter system OppABCD is required for glutathione import in M. tuberculosis to regulate the detoxification of methyl glyoxal, cytokine release and apoptosis of macrophages. 68 …”
Section: Mycobacterium Tuberculosismentioning
confidence: 99%
See 1 more Smart Citation
“…67 The importance of peptide transporters in the pathogenesis of M. tuberculosis also gets emphasized by the finding that ABC peptide transporter system OppABCD is required for glutathione import in M. tuberculosis to regulate the detoxification of methyl glyoxal, cytokine release and apoptosis of macrophages. 68 …”
Section: Mycobacterium Tuberculosismentioning
confidence: 99%
“…98 Phenotype microarray has turned out to be one of the most useful high throughput method for preliminary indirect assessment of function of peptide transporters. 99 Direct methods like microscopic examination of fluorescently labeled peptides taken by bacterial cells, 13 use of radiolabeled substrates 68 and chromatography mediated analysis of the peptides present inside the cell 100 would describe the function of the transporter more specifically. Use of proton ionophores 38 or measuring alkalization as a result of proton translocation would be helpful to study PTR peptide transporters.…”
Section: Characterization Of Unknown Peptide Transportersmentioning
confidence: 99%
“…OppA periplasmic proteins are important in chemotaxis and virulence due to their substrate-binding and transport abilities as part of ABC systems (23,28). In addition, ecto-ATPase activity (29) or chaperone-like functions in protein folding (30) have been described for these proteins.…”
Section: Discussionmentioning
confidence: 99%
“…The M. tuberculosis oligopeptide permease (Opp) has been shown to be linked to the expression of virulence-associated lipids and PE-family proteins, and its loss resulted in the delay of the death of chronically-infected animals [27]. In another study OppA has been linked with cytokine secretion and apoptosis of M.tuberculosis -infected macrophages [28]. …”
Section: Discussionmentioning
confidence: 99%